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The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Journal

Publisher

MDPI
DOI: 10.3390/ijms241612899

Keywords

miRNA; Alzheimer's disease; ischemia-reperfusion injury; blood-brain barrier; RNA biology; neuroinflammation; oxidative stress

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In recent times, there has been a growing interest among researchers in understanding the functions of microRNAs and their role in the development of various diseases. This review analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying Alzheimer's disease, cerebral ischemia and reperfusion injury, and blood-brain barrier dysfunction.
In recent times, there has been a significant increase in researchers' interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer's disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood-brain barrier.

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