Mind the Curve: Dose-Response Fitting Biases the Synergy Scores across Software Used for Chemotherapy Combination Studies

Article Pharmacology & Pharmacy

Statistical detection of synergy: New methods and a comparative study

Olivier Thas et al.

Summary: Combination therapies are increasingly being used as standard treatment for various diseases to improve outcomes and reduce resistance. Testing for synergy in drug combinations is essential, and new tests have been developed that show reliable coverage and can complement existing methods.

PHARMACEUTICAL STATISTICS (2022)

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Article Biochemistry & Molecular Biology

Diosmetin Exerts Synergistic Effects in Combination with 5-Fluorouracil in Colorectal Cancer Cells

Sareh Kamran et al.

Summary: The combination of 5-FU and diosmetin has a synergistic effect against colorectal cancer cells, reducing the toxicity of 5-FU while enhancing its anticancer efficacy. This combination induces apoptosis and interrupts cell mitosis to achieve its anticancer effects.

BIOMEDICINES (2022)

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Article Pharmacology & Pharmacy

Caenorhabditis elegans as a valuable model for the study of anthelmintic pharmacodynamics and drug-drug interactions: The case of ivermectin and eprinomectin

Gonzalo Suarez et al.

Summary: This study assessed the pharmacodynamics and drug-drug interactions of eprinomectin (EPM) and ivermectin (IVM) using the Caenorhabditis elegans model. Results showed that EPM was slightly more potent than IVM, drug potency increased with time exposure, and there was neither synergy nor antagonism between the two drugs. This study highlights the utility of C. elegans for studying pharmacodynamics, particularly for drug-drug interactions.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery

David J. Wooten et al.

Summary: Drug combination discovery relies on reliable synergy metrics, but the lack of consensus on the correct synergy criterion hinders progress. This study presents a mass-action based formalism to quantify synergy, highlighting biases in traditional metrics and proposing a unified approach. MuSyC, a consensus synergy metric, overcomes caveats associated with popular metrics and may accelerate the development of combinatorial therapies.

NATURE COMMUNICATIONS (2021)

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Review Multidisciplinary Sciences

Drug combination and repurposing for cancer therapy: the example of breast cancer

Ana Salome Correia et al.

Summary: Cancer is a highly complex set of diseases, with breast cancer being particularly prevalent among women. Despite recent advancements, treatment for cancer remains challenging, leading to costly and intensive research. Drug repurposing and combinations are emerging strategies that show promise in improving therapy outcomes and reducing associated costs.

HELIYON (2021)

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Review Pharmacology & Pharmacy