Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms241612610
Keywords
Sclerotinia sclerotiorum; SsCak1; sclerotia; appressoria; pathogenesis; HIGS
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SsCak1, a putative protein kinase, is crucial for the growth and pathogenicity of S. sclerotiorum. Deletions in SsCak1 result in developmental defects and complete loss of virulence. Targeting SsCak1 through host-induced gene silencing (HIGS) could be a potential strategy for controlling S. sclerotiorum infection and increasing crop resistance.
Sclerotinia sclerotiorum is a devastating fungal pathogen that causes severe crop losses worldwide. It is of vital importance to understand its pathogenic mechanism for disease control. Through a forward genetic screen combined with next-generation sequencing, a putative protein kinase, SsCak1, was found to be involved in the growth and pathogenicity of S. sclerotiorum. Knockout and complementation experiments confirmed that deletions in SsCak1 caused defects in mycelium and sclerotia development, as well as appressoria formation and host penetration, leading to complete loss of virulence. These findings suggest that SsCak1 is essential for the growth, development, and pathogenicity of S. sclerotiorum. Therefore, SsCak1 could serve as a potential target for the control of S. sclerotiorum infection through host-induced gene silencing (HIGS), which could increase crop resistance to the pathogen.
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