Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer's Disease: Implications for Controlling Astroglial Activity

Article Neurosciences

Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells

Ana Bernal-Chico et al.

Summary: This review summarizes the current understanding of the role and clinical relevance of endocannabinoid signaling in glial cells, as well as its therapeutic potential in neurodegenerative and chronic inflammatory disorders.

GLIA (2023)

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Review Biochemistry & Molecular Biology

Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?

Ignacio Fernandez-Moncada et al.

Summary: Astrocytes play a crucial role in brain homeostasis and function, responding to neuronal signals and modulating synaptic activity through gliotransmission. The cannabinoid type-1 (CB1) receptor has emerged as a critical player in the control of glio-transmission and metabolic cooperation between astrocytes and neurons. This review discusses the known and newly discovered properties of astroglial CB1 receptors and their impact on brain function and behavior, highlighting the interconnected relationship between energy metabolism and gliotransmission.

ESSAYS IN BIOCHEMISTRY (2023)

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Review Neurosciences

Revealing the contribution of astrocytes to glutamatergic neuronal transmission

Ares Orlando Cuellar-Santoyo et al.

Summary: Previous research mainly focused on the function of presynaptic and postsynaptic neurons, relegating astrocytes to a secondary role of ensuring neurotransmission. Recent evidence suggests that astrocytes actively contribute to and regulate neuronal transmission. This review compares glutamatergic components in neurons and astrocytes to explore how astrocytes modulate or influence neuronal transmission. Despite knowing their role in synaptic modulation, the specific contributions of astrocytes to physiological and pathological conditions remain unclear. Understanding the role of astrocytes in neuronal processing could lead to new therapeutic applications.

FRONTIERS IN CELLULAR NEUROSCIENCE (2023)

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Article Neurosciences

Endocannabinoid signaling in astrocytes

Abel Eraso-Pichot et al.

Summary: The study of astrocytic contribution to brain functions has gained popularity in neuroscience. Recent discoveries have shown the involvement of astrocytes in synaptic functions and revealed their previously unimaginable multiple functions. Additionally, research on cannabinoids has identified different ways they interact with astrocytes, modify their functions, alter their communication with neurons, and impact behavior. This review discusses the expression of endocannabinoid system members in astrocytes and the latest findings on cannabinoid modulation of important astroglial functions, such as calcium dynamics, gliotransmission, metabolism, and inflammation.

GLIA (2023)

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Review Biochemistry & Molecular Biology

Role of the Endocannabinoid System in Metabolic Control Processes and in the Pathogenesis of Metabolic Syndrome: An Update

Gabriella Dornyei et al.

Summary: Metabolic syndrome is a complex disease state that arises from an unhealthy, sedentary lifestyle. It brings about various metabolic complications and reduces life expectancy. The endocannabinoid system plays a crucial role in signalization processes in both the central nervous system and peripheral tissues, affecting several physiological functions. Understanding cannabinoid receptor functions can offer potential therapeutic effects for the treatment of metabolic diseases like diabetes, insulin resistance, obesity, and hypertension.

BIOMEDICINES (2023)

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Article Cell Biology

Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer's disease

Yubing Liu et al.

Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to dementia. The hippocampus, one of the main sites for neurogenesis, exhibits significant neuronal loss in AD. Using the 3xTg mouse model, researchers discovered that neurogenic deficits are present during postnatal stages, even before the onset of neuropathology or behavioral deficits. Specifically, the 3xTg mice had fewer neural stem/progenitor cells, reduced proliferation, and decreased numbers of newborn neurons. The findings suggest that impairments in neurogenesis occur early in AD, opening up possibilities for early diagnosis and intervention.

CELL DEATH & DISEASE (2023)

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Review Pharmacology & Pharmacy

Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer's disease: A systematic review and meta-analysis of animal studies

Mohd Amir Kamaruzzaman et al.

Summary: This review examines the effects of cannabinoid modulation on glial cells and cognitive function in animal models of Alzheimer's disease. It finds that cannabinoid agonists reduce escape latency and improve object recognition ability in rodents, as well as decrease the accumulation of A beta plaques and inhibit glial cell markers and pro-inflammatory markers. These findings suggest that modulation of glial cells through cannabinoid stimulation may enhance cognitive function by reducing inflammation.

FRONTIERS IN PHARMACOLOGY (2023)

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Review Biochemistry & Molecular Biology

Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases

Bahareh Abd-Nikfarjam et al.

Summary: The medicinal properties of cannabis and cannabinoids have been extensively studied, leading to more research on the therapeutic features of the cannabinoid system in neuroinflammatory disorders. Cannabinoids can control and regulate inflammatory responses, with the cannabinoid receptor type 2 (CB2) showing promise for new therapeutic approaches. This review discusses the involvement of the endocannabinoid system in neuroinflammatory disorders, the pharmacological efficacy of different cannabinoids, and the reasons for targeting CB2 in neurodegeneration.

BIOFACTORS (2023)

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Review Medicine, Research & Experimental

The evolution of cannabinoid receptors in cancer

Nakea M. Pennant et al.

Summary: Cannabis sativa has been used as a therapeutic treatment for centuries, but racial propaganda led to its criminalization and hindered therapeutic development. The increase in recreational use of cannabis led to further restrictions, but in some states, it has been legalized for medical purposes. The cannabinoids and their receptors in the endocannabinoid system play a crucial role in regulating physiological and biological processes, making them a potential therapeutic target for treating diseases.

WIRES MECHANISMS OF DISEASE (2023)

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Article Neurosciences

Maternal hypercaloric diet affects factors involved in lipid metabolism and the endogenous cannabinoid systems in the hypothalamus of adult offspring: sex-specific response of astrocytes to palmitic acid and anandamide

Patricia Rivera et al.

Summary: This study aimed to investigate the long-lasting effects of maternal malnutrition during gestation/lactation on inflammation, lipid metabolism, and endocannabinoid signaling in the adult offspring hypothalamus, as well as the role of hypothalamic astrocytes in these changes. The results showed that maternal malnutrition caused sex-specific alterations in hypothalamic endocannabinoid signaling and lipid metabolism. Additionally, hypothalamic astrocytes were found to play a possible role in this process.

NUTRITIONAL NEUROSCIENCE (2022)

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Article Clinical Neurology

Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury

Lucia Beckmann et al.

Summary: Clinical and experimental studies suggest sexual dimorphism in neonatal brain injury and therapy responses caused by hypoxia-ischemia (HI). This study found that regulatory T cells (Tregs) from neonatal female mice provide neuroprotection, while Tregs from male mice increase secondary neurodegeneration, which may be associated with intrinsic transcriptional differences between sexes. There is an urgent need for sex-stratified clinical and preclinical analyses.

STROKE (2022)

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Review Microbiology

Pathogenic Infections during Pregnancy and the Consequences for Fetal Brain Development

Sukanta Jash et al.

Summary: Pathogens, including viruses, bacteria, gut microbiome, and parasites, play a significant role in the emergence of new diseases in humans. Studying their ability to cause diseases is important for drug development and prevention of infection-related disorders. During pregnancy, infections by viruses, bacteria, and parasites can have a major impact on maternal and fetal health, particularly affecting fetal brain development and leading to long-term cognitive impairments.

PATHOGENS (2022)

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Review Biochemistry & Molecular Biology

Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis

Raquel Sanchez-Varo et al.

Summary: This review provides an overview of the major pathological elements of Alzheimer's disease and discusses the insights provided by mouse models in understanding the underlying mechanisms. It highlights the pros and cons of current models and explores the potential benefits of combining transgenic mice with omics technologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice

Muxian Zhang et al.

Summary: The study compared sexual dimorphism in gene expression across primary neurons, astrocytes, and microglia derived from neonatal mouse brains, revealing different levels of sexually dimorphic genes in these primary cells, with enrichment in immune-related pathways. The sexually dimorphic genes were predominantly located on the Y chromosome, and overexpression of Eif2s3y specifically affected synaptic transmission in male neurons and caused autism-like behaviors in male mice, providing new insights into sex differences in neurological disorders.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Clinical Neurology

Cannabinoids and the expanded endocannabinoid system in neurological disorders

Luigia Cristino et al.

NATURE REVIEWS NEUROLOGY (2020)

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Article Multidisciplinary Sciences

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Daniel Jimenez-Blasco et al.

NATURE (2020)

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Article Medicine, Research & Experimental

Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease

Sarah Beggiato et al.

LIFE SCIENCES (2020)

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Review Neurosciences

Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies

Alex J. Berry et al.

BRAIN RESEARCH (2020)

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Review Cell Biology

An Overview of Astrocyte Responses in Genetically Induced Alzheimer's Disease Mouse Models

Fokion Spanos et al.

CELLS (2020)

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Article Biology

Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer's Disease in a Preclinical Model: A Therapeutic Opportunity

Dina Medina-Vera et al.

BIOLOGY-BASEL (2020)

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Review Biochemistry & Molecular Biology

In vivo molecular imaging of neuroinflammation in Alzheimer's disease

Aisling Chaney et al.

JOURNAL OF NEUROCHEMISTRY (2019)

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Article Neurosciences

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

Angela Gomez-Arboledas et al.

GLIA (2018)

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Article Anatomy & Morphology

Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease

Vincent Kong et al.

BRAIN STRUCTURE & FUNCTION (2018)

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Article Biotechnology & Applied Microbiology

New approaches and challenges to targeting the endocannabinoid system

Vincenzo Di Marzo

NATURE REVIEWS DRUG DISCOVERY (2018)

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Article Neurosciences

Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer's Disease

Jun-Ting Yang et al.

NEUROSCIENCE BULLETIN (2018)

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Review Clinical Neurology

In vivo Imaging of Glial Activation in Alzheimer's Disease

Paul Edison et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Physiology

Cooperative role of the glucagon-like peptide-1 receptor and 3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats

J. Decara et al.

ACTA PHYSIOLOGICA (2018)

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Article Neurosciences

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

Ashley N. Nilson et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Clinical Neurology

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease

K. E. Ameen-Ali et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2017)

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The role of astrocytes in amyloid production and Alzheimer's disease

Georgia R. Frost et al.

OPEN BIOLOGY (2017)

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Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target

Tommaso Cassano et al.

FRONTIERS IN NEUROSCIENCE (2017)

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The Cellular Phase of Alzheimer's Disease

Bart De Strooper et al.

CELL (2016)

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Astroglia dynamics in ageing and Alzheimer's disease

Alexei Verkhratsky et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

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ASTROCYTES IN PHYSIOLOGICAL AGING AND ALZHEIMER'S DISEASE

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NEUROSCIENCE (2016)

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Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

Lana M. Osborn et al.

PROGRESS IN NEUROBIOLOGY (2016)

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Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes

Esther Fuente-Martin et al.

SCIENTIFIC REPORTS (2016)

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3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

Hongjun Fu et al.

PLOS ONE (2016)

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Reactive Astrogliosis: Role in Alzheimer's Disease

Priti Jain et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)

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WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture

Diana Aguirre-Rueda et al.

PLOS ONE (2015)

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Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease

Gaurav Bedse et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

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Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs

Antoni Pastor et al.

JOURNAL OF LIPID RESEARCH (2014)

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Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

Sung S. Choi et al.

PLOS ONE (2014)

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Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APPswe/PS1ΔE9 double transgenic mice

Sara Kalifa et al.

BRAIN RESEARCH (2011)

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Article Biochemistry & Molecular Biology

Sex differences in histone modifications in the neonatal mouse brain

Houng-Wei Tsai et al.

EPIGENETICS (2009)

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Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy Lights and Shadows

Domenico Pratico

MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)

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Inflammatory processes in Alzheimer's disease

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JOURNAL OF NEUROIMMUNOLOGY (2007)

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The endocannabinoid system in targeting inflammatory neurodegenerative diseases

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TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

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NATURE REVIEWS IMMUNOLOGY (2005)

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Triple-transgenic model of Alzheimer's disease with plaques and tangles:: Intracellular Aβ and synaptic dysfunction

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NEURON (2003)

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Inflammation in neurodegenerative disease - A double-edged sword

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NEURON (2002)

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Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer's Disease: Implications for Controlling Astroglial Activity

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