Challenges and Future Trends in Atopic Dermatitis

Atopic dermatitis represents a complex and multidimensional interaction that represents potential fields of preventive and therapeutic management. In addition to the treatment armamentarium available for atopic dermatitis, novel drugs targeting significant molecular pathways in atopic dermatitis biologics and small molecules are also being developed given the condition's complex pathophysiology. While most of the patients are expecting better efficacy and long-term control, the response to these drugs would still depend on numerous factors such as complex genotype, diverse environmental triggers and microbiome-derived signals, and, most importantly, dynamic immune responses. This review article highlights the challenges and the recently developed pharmacological agents in atopic dermatitis based on the molecular pathogenesis of this condition, creating a specific therapeutic approach toward a more personalized medicine.

Automated summary

Atopic dermatitis is a complex condition with various factors affecting its treatment and management. In addition to conventional therapies, new drugs targeting specific molecular pathways in atopic dermatitis are being developed to address its complex pathophysiology. The efficacy of these drugs depends on factors such as genotype, environmental triggers, microbiome-derived signals, and immune responses. This review highlights the challenges and recent pharmacological developments in atopic dermatitis, aiming for a more personalized therapeutic approach.