Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer's Disease

Alzheimer's disease is the most common cause of dementia in the world. Lack of an established pathology makes it difficult to develop suitable approaches and treatment for the disease. Besides known hallmarks, including amyloid & beta; peptides cumulating in plaques and hyperphosphorylated tau forming NFTs, inflammation also plays an important role, with known connections to the diet. In AD, adhering to reasonable nutrition according to age-related principles is recommended. The diet should be high in neuroprotective foods, such as polyunsaturated fatty acids, antioxidants, and B vitamins. In addition, foods capable of rising BDNF should be considered because of the known profitable results of this molecule in AD. Adhering to beneficial diets might result in improvements in memory, cognition, and biomarkers and might even reduce the risk of developing AD. In this review, we discuss the effects of various diets, foods, and nutrients on brain health and possible connections to Alzheimer's disease.

Automated summary

Alzheimer's disease is the most common cause of dementia worldwide. The lack of established pathology makes it challenging to find suitable approaches for treatment. In addition to the known hallmarks of the disease, such as amyloid β peptides and hyperphosphorylated tau, inflammation and diet also play important roles. Adhering to a beneficial diet high in neuroprotective foods and BDNF-boosting substances may improve memory, cognition, and biomarkers, and even reduce the risk of developing Alzheimer's disease.