4.7 Article

Plasma Lysophosphatidic Acid Concentrations in Sex Differences and Psychiatric Comorbidity in Patients with Cocaine Use Disorder

Related references

Note: Only part of the references are listed.
Article Pediatrics

Treating ADHD and Comorbid Anxiety in Children: A Guide for Clinical Practice

Roberto Leon-Barriera et al.

Summary: ADHD often coexists with anxiety disorders, and tailored treatment options are needed. Stimulant medications and atomoxetine are effective and well-tolerated choices for treatment. Cognitive behavioral therapy plays a crucial role in alleviating anxiety symptoms.

CLINICAL PEDIATRICS (2023)

Article Psychiatry

Plasma concentrations of lysophosphatidic acid and the expression of its receptors in peripheral blood mononuclear cells are altered in patients with cocaine use disorders

Maria Flores-Lopez et al.

Summary: We conducted a study to explore the potential role of the LPA signaling system as a biomarker in cocaine use disorders (CUD). The study found that patients with CUD had lower plasma concentrations of LPA species and higher mRNA expression of LPA(1) receptor compared to healthy controls. Additionally, a positive association was found between plasma concentration of 20:4-LPA and CUD-related variables. The study also revealed sex differences in LPA concentrations and alterations in rats treated with cocaine, indicating the impact of CUD and sex on LPA signaling.

TRANSLATIONAL PSYCHIATRY (2023)

Article Chemistry, Medicinal

Investigation of the Relationship among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior

Amel Messaoud et al.

Summary: This study found that suicidal MDD patients experience enhanced breakdown of tryptophan into kynurenine. Cortisol and proinflammatory cytokines are involved in this process.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

Article Neurosciences

Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders

Maria Flores-Lopez et al.

Summary: The study investigated the concentrations of LPA in patients with substance use disorder, finding that women had higher LPA concentrations than men and SUD patients had lower LPA concentrations. LPA species could potentially serve as biomarkers for SUD in both women and men.

BRAIN SCIENCES (2022)

Review Substance Abuse

Cocaine Use Disorder (CUD): Current Clinical Perspectives

Elizabeth K. C. Schwartz et al.

Summary: Cocaine use disorder (CUD) is a devastating disorder that has significant impacts on individuals and society. Accessing treatment for CUD is challenging, with many barriers preventing individuals from receiving adequate care. While there are currently no FDA-approved pharmacological treatments for CUD, medication treatments may benefit those with co-occurring disorders. Behavioral interventions, such as contingency management and cognitive-behavioral therapy, have shown efficacy in treating CUD, but there are obstacles in delivering these treatments to patients.

SUBSTANCE ABUSE AND REHABILITATION (2022)

Article Biochemistry & Molecular Biology

The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response

Bashkim Kadriu et al.

Summary: This study explored the impact of ketamine on the endogenous KYN pathway in individuals with bipolar depression and its relationship with depression-related behavioral and peripheral inflammatory markers. Results showed that post-ketamine IDO levels were significantly lower, while KYN and KynA levels were significantly increased. Inflammatory markers and behavioral measures predicted changes in the KYN pathway post ketamine treatment.

MOLECULAR PSYCHIATRY (2021)

Article Psychiatry

Attachment Anxiety Moderates the Association Between ADHD and Psychological Distress

Hadil Kordahji et al.

Summary: This study found that attachment anxiety moderated the association between ADHD, anxiety and depression, with only ADHD adults with moderate to high attachment anxiety exhibiting higher levels of psychological distress. No moderating effect was observed for attachment avoidance, indicating the important role of attachment style in mental health of adults with ADHD.

PSYCHIATRIC QUARTERLY (2021)

Article Immunology

The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation

Yuri Milaneschi et al.

Summary: The study revealed that TRYCATs levels were associated with specific features of depression, including symptom profiles and inflammatory markers, indicating a potential benefit of modulating the kynurenine pathway for certain subsets of depressed patients. Further clinical studies should focus on patients with clear evidence of kynurenine pathway dysregulation.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Biochemistry & Molecular Biology

Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease

Maria Flores-Lopez et al.

Summary: The study revealed dysregulation of the ATX-LPA axis in patients with AUD, with lower LPA concentrations and higher ATX concentrations in AUD patients compared to healthy controls. Additionally, patients with AUD and liver disease had significantly higher ATX concentrations. The study also found significant correlations between AUD-related variables and concentrations of LPA and ATX.

BIOMEDICINES (2021)

Article Clinical Neurology

Preliminary comparative analysis of kynurenine pathway metabolites in chronic ketamine users, schizophrenic patients, and healthy controls

Zhaohua Zhang et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020)

Article Chemistry, Analytical

Detection of the Ovarian Cancer Biomarker Lysophosphatidic Acid in Serum

Brian De La Franier et al.

BIOSENSORS-BASEL (2020)

Article Biochemistry & Molecular Biology

Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory

David Ladron de Guevara-Miranda et al.

ADDICTION BIOLOGY (2019)

Article Multidisciplinary Sciences

Sex-based differences in multidimensional clinical assessments of early-abstinence crack cocaine users

Breno Sanvicente-Vieira et al.

PLOS ONE (2019)

Article Neurosciences

Effects of the LPA1 Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice

Sara Tabbai et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Endocrinology & Metabolism

Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial

Freek J. H. Sorgdrager et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Biochemistry & Molecular Biology

Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders

Carine Thalman et al.

MOLECULAR PSYCHIATRY (2018)

Article Clinical Neurology

Depressive, anxiety and hypomanic symptoms in schizophrenia may be driven by tryptophan catabolite (TRYCAT) patterning of IgA and IgM responses directed to TRYCATs

Buranee Kanchanatawan et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

Review Chemistry, Medicinal

Anxiety Disorders: Sex Differences in Serotonin and Tryptophan Metabolism

Tanya Songtachalert et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)

Article Oncology

Autotaxin is a novel molecular identifier of type I endometrial cancer

Antonio Mazzocca et al.

MEDICAL ONCOLOGY (2018)

Review Psychology, Clinical

Sex and gender differences in substance use disorders

R. Kathryn McHugh et al.

CLINICAL PSYCHOLOGY REVIEW (2018)

Review Endocrinology & Metabolism

Cortisol stress reactivity across psychiatric disorders: A systematic review and meta-analysis

Jelle V. Zorn et al.

PSYCHONEUROENDOCRINOLOGY (2017)

Review Psychiatry

ADHD and Anxiety: Clinical Significance and Treatment Implications

Frederick W. Reimherr et al.

CURRENT PSYCHIATRY REPORTS (2017)

Article Psychiatry

maLPA1-null mice as an endophenotype of anxious depression

R. D. Moreno-Fernandez et al.

TRANSLATIONAL PSYCHIATRY (2017)

Article Clinical Neurology

Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion

Rashmi Singh et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

Review Biochemistry & Molecular Biology

G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling

Anjum Riaz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Behavioral Sciences

Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case-control study

Tore Ivar Malmei Aarsland et al.

BEHAVIORAL AND BRAIN FUNCTIONS (2015)

Article Substance Abuse

Differential effects of cocaine exposure on the abundance of phospholipid species in rat brain and blood

Brian S. Cummings et al.

DRUG AND ALCOHOL DEPENDENCE (2015)

Article Endocrinology & Metabolism

Serum Autotaxin is Independently Associated with Hepatic Steatosis in Women with Severe Obesity

Vikrant P. Rachakonda et al.

OBESITY (2015)

Article Substance Abuse

Psychopathological comorbidity in cocaine users in outpatient treatment

Pedro Araos et al.

ADICCIONES (2014)

Review Endocrinology & Metabolism

Sex differences in stress-related psychiatric disorders: Neurobiological perspectives

Debra A. Bangasser et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2014)

Review Biochemistry & Molecular Biology

Lysophospholipids and their receptors in the central nervous system

Ji Woong Choi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

Article Substance Abuse

Prevalence of Substance Use and Psychiatric Disorders in a Highly Select Chronic Pain Population

Steven L. Proctor et al.

JOURNAL OF ADDICTION MEDICINE (2013)

Article Medicine, General & Internal

Anxiety symptoms in crack cocaine and inhalant users admitted to a psychiatric hospital in southern Brazil

Carlos Zubaran et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2013)

Article Veterinary Sciences

Influence of Sex Differences and Gonadal Hormones on Cocaine Addiction

Vanya Quinones-Jenab et al.

ILAR JOURNAL (2012)

Article Medicine, Research & Experimental

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics

Mary Jeanne Kreek et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Pharmacology & Pharmacy

LPA Receptors: Subtypes and Biological Actions

Ji Woong Choi et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)

Review Biochemistry & Molecular Biology

Two pathways for lysophosphatidic acid production

Junken Aoki et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)

Article Substance Abuse

Gender differences in cocaine dependence

Lisa M. Najavits et al.

DRUG AND ALCOHOL DEPENDENCE (2008)

Article Multidisciplinary Sciences

The molecular neurobiology of depression

Vaishnav Krishnan et al.

NATURE (2008)

Article Substance Abuse

Personality profile in young current regular users of cocaine

M. Jesus Herrero et al.

SUBSTANCE USE & MISUSE (2008)

Article Medical Laboratory Technology

Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity

Shigemi Hosogaya et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2008)

Article Neurosciences

Free L-tryptophan plasma levels in antisocial violent offenders

J Tiihonen et al.

PSYCHOPHARMACOLOGY (2001)

Article Psychology, Clinical

Exposure therapy in the treatment of PTSD among cocaine-dependent individuals: description of procedures

SE Back et al.

JOURNAL OF SUBSTANCE ABUSE TREATMENT (2001)