☆ 4.7 Review

Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Inflammatory Cascade in Alzheimer's Disease Pathogenesis: A Review of Experimental Findings

Jade de Oliveira et al.

Summary: Alzheimer's disease is the leading cause of dementia worldwide, with the amyloid cascade hypothesis being the most recognized explanation for AD pathology. The mechanisms underlying late onset AD are not completely clear, with BBB disruption playing an essential role in neuroinflammation and AD development. Systemic inflammation triggered by conditions like metabolic diseases or infections may contribute to the neurodegeneration observed in AD.

CELLS (2021)

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Review Cell Biology

Exosomes, a New Star for Targeted Delivery

Huizhi Chen et al.

Summary: Exosomes are cell-secreted nanoparticles that can serve as carriers for targeted drug/gene delivery, but the current challenge lies in the insufficient targeting ability and efficacy. Various approaches have been applied to engineer exosomes for higher selectivity and effectiveness.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Clinical Neurology

Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer's Disease?

Louisa Nitsch et al.

Summary: Neuronal cell death, amyloid beta plaque formation, and neurofibrillary tangles are characteristics of Alzheimer's disease, while the involvement of inflammatory processes like microglia and astrocyte activation is crucial in its pathogenesis. Cytokines play an essential role in the immune response of AD. Recent studies have shown the role of interleukin 23 and its p40 subunit in the pathogenesis of AD and have demonstrated potential therapeutic effects with anti-p40 antibody injections in animal models.

FRONTIERS IN NEUROLOGY (2021)

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Review Oncology

Microfluidic Chip-Based Cancer Diagnosis and Prediction of Relapse by Detecting Circulating Tumor Cells and Circulating Cancer Stem Cells

Hyeon-Yeol Cho et al.

Summary: The review highlights the significance of metastasis as the main cause of cancer-related death and discusses recent advances in the detection and analysis of circulating tumor cells and circulating cancer stem cells. The focus is on the design of microfluidic devices with optical sensing tools and strategies for analyzing the differentiation of circulating cancer stem cells.

CANCERS (2021)

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Review Cell Biology

Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models

Maria Concetta Geloso et al.

Summary: Microglia can rapidly respond to environmental changes and play a role in shaping neuronal wiring. They regulate the elimination of weaker synapses, actively participating in modulating neuronal function. Synaptic dysfunction may be an early and independent event in the neurodegenerative process associated with diseases like multiple sclerosis.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Neuroprotective Herbs for the Management of Alzheimer's Disease

Julie Gregory et al.

Summary: This study systematically reviews recent research on the role of neuroprotective herbs and their bioactive compounds in dementia associated with Alzheimer's disease. Medicinal plants have great potential in preventing and treating cognitive decline related to AD, and they can potentially be used in drug discovery programs to identify safe and effective small molecules for AD.

BIOMOLECULES (2021)

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Review Allergy

Secondary immunodeficiencies An overview

Karen S. Tuano et al.

Summary: Secondary immunodeficiencies have various causes, including malnutrition, metabolic disorders, medication use, chronic infections, malignancies, and more. Immune responses may be weaker in neonates and the elderly. Clinicians should consider secondary immunodeficiencies in patients with recurrent infections and abnormal immunologic evaluation.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Circular L-RNA aptamer promotes target recognition and controls gene activity

Danyang Ji et al.

Summary: In this study, a simple and robust strategy was developed to generate the first circular L-RNA aptamer, cycL-Apt.4-1c, which demonstrated substantial enhancement in binding affinity and selectivity toward its target. The novel applications of circular L-RNA aptamer in controlling RNA-protein interaction, and gene activity were also notably reported. This approach and findings will be applicable to any L-RNA aptamers and open up a new avenue for diverse applications.

NUCLEIC ACIDS RESEARCH (2021)

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Article Multidisciplinary Sciences

Microglial morphology in Alzheimer's disease and after Aβ immunotherapy

Diana K. Franco-Bocanegra et al.

Summary: The study found that reactive/amoeboid microglia are the most common type in the aged human brain, Alzheimer's disease does not affect the number of microglia but decreases ramified microglia, and immunotherapy can increase ramified microglia.

SCIENTIFIC REPORTS (2021)

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Review Biotechnology & Applied Microbiology

Advances in aptamer screening and aptasensors' detection of heavy metal ions

Wenfei Guo et al.

Summary: This paper reviews the seriousness of heavy metal pollution and the application of aptasensors in detecting heavy metal ions. It focuses on the methods for selecting aptamers with high specificity and high affinity, as well as the construction methods and research progress of aptamers based on sensors. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction

Jie Pan et al.

Summary: Research has found that BBB permeability to peripheral cells is significantly enhanced in aged mice, with microglia showing marked alterations in the negative regulation of protein phosphorylation and phagocytic vesicles, and astrocytes exhibiting elevated enzyme or peptidase-inhibitor activity in BBB function recovery.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Chemistry, Multidisciplinary

Laser Scribing Fabrication of Graphitic Carbon Biosensors for Label-Free Detection of Interleukin-6

Pei Shee Tan et al.

Summary: Interleukin-6 is a crucial cytokine in inflammatory processes, and a new electrochemical immunosensor platform based on graphitic carbon electrodes has been developed for rapid, low-cost, and sensitive detection.

NANOMATERIALS (2021)

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Review Clinical Neurology

Immunotherapies for Neurodegenerative Diseases

Ibrahim Mortada et al.

Summary: Current treatments for neurodegenerative diseases mainly focus on symptomatic relief without addressing the root cause of the disease. Immunotherapy has shown potential in managing disease progression by harnessing the immune system to fight misfolded proteins. Research is ongoing to evaluate the use of immunotherapy in targeting neuroinflammation-induced neurodegeneration.

FRONTIERS IN NEUROLOGY (2021)

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Review Cell Biology

B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights

Julie J. Ahn et al.

Summary: In recent years, the role of B cells in neurological disorders has been greatly expanded, highlighting their importance in neuroinflammation. B cells not only contribute to inflammatory diseases through peripheral immune mechanisms, but also through central nervous system mechanisms. Emerging evidence suggests that aberrant B cell populations may play a role in neuroinflammatory processes, emphasizing the potential for B cell-directed therapies in neurological disorders.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Uptake mechanisms of cell-internalizing nucleic acid aptamers for applications as pharmacological agents

Samira Husen Alamudi et al.

Summary: Nucleic acid aptamers, also known as chemical antibodies, show promise as targeted therapeutic and delivery agents due to unique advantages over antibodies. Most aptamers can be internalized by cells and enter cells directly, which is important for their potential as pharmacological agents. Understanding selection methods, cellular uptake pathways, and intracellular fates of aptamers is crucial for their applications in medicine.

RSC MEDICINAL CHEMISTRY (2021)

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Review Immunology

Neuromodulation by the immune system: a focus on cytokines

Andrea Francesca Salvador et al.

Summary: Interactions between the immune system and the nervous system play a crucial role in shaping host behavior and nervous system function. These interactions may have evolved to maximize an organism's ability to respond to environmental threats. The immune system relays information to the nervous system through cytokine signaling, and the brain may be hardwired to process information from the immune system in a specific way.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Dermatology

Advances in dermatology using DNA aptamer Aptamin C innovation: Oxidative stress prevention and effect maximization of vitamin C through antioxidation

Sooho Choi et al.

JOURNAL OF COSMETIC DERMATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Therapeutic Aptamers: Evolving to Find their Clinical Niche

Shahid M. Nimjee et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Therapeutic applications of AS1411 aptamer, an update review

Rezvan Yazdian-Robati et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges

Fen He et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Neurosciences

Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke

Quezya Mendes Camargos et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Biophysics

Dual function of interleukin-23 Aptamer to suppress brain inflammation via attachment to macrophage stimulating 1 kinase and interleukin-23

Hossein Shandadi Sardou et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Biochemistry & Molecular Biology

Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice

Pascale Eede et al.

EMBO REPORTS (2020)

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Article Biochemistry & Molecular Biology

An RNA aptamer with potent affinity for a toxic dimer of amyloid?42 has potential utility for histochemical studies of Alzheimer's disease

Kazuma Murakami et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Enhanced in Vivo Blood-Brain Barrier Penetration by Circular Tau-Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy

Xiaowei Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Review Clinical Neurology

Advances in oral immunomodulating therapies in relapsing multiple sclerosis

Tobias Derfuss et al.

LANCET NEUROLOGY (2020)

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Review Biochemistry & Molecular Biology

Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

Fadwa Odeh et al.

MOLECULES (2020)

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Review Neurosciences

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

John Pluvinage et al.

NATURE REVIEWS NEUROSCIENCE (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Biophysics

Amyloid-beta peptide detection via aptamer-functionalized nanowire sensors exploiting single-trap phenomena

Yurii Kutovyi et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Review Neurosciences

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis

Chao Zheng et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

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Review Immunology

Neuro-immune Interactions in the Tissues

Coco Chu et al.

IMMUNITY (2020)

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Review Biochemistry & Molecular Biology

Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy

Zhaoying Fu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Neurosciences

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms

Angelica Maria Sabogal-Guaqueta et al.

PROGRESS IN NEUROBIOLOGY (2020)

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Review Neurosciences

Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors

Shani Vaknine et al.

NEUROPHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration

Patrycja Michalska et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery

Bakhtiar Bukari et al.

BIOMEDICINES (2020)

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Review Neurosciences

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Susana R. Cerqueira et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease

Amanda McQuade et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Role of Toll Like Receptor 4 in Alzheimer's Disease

Maria Calvo-Rodriguez et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Therapeutic Interventions into Innate Immune Diseases by Means of Aptamers

Farzana Yasmeen et al.

PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer's Disease

Yayoi Obata et al.

ACS OMEGA (2020)

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Review Biochemistry & Molecular Biology

Aptamer-Functionalized Nanoparticles in Targeted Delivery and Cancer Therapy

Zhaoying Fu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Development of a CD63 Aptamer for Efficient Cancer Immunochemistry and Immunoaffinity-Based Exosome Isolation

Zhenguo Song et al.

MOLECULES (2020)

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Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

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Review Neurosciences

A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity

Hossam Kadry et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

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Article Clinical Neurology

Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?

Jack Rivers-Auty et al.

BRAIN COMMUNICATIONS (2020)

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Review Biochemistry & Molecular Biology

Neuroinflammation Mechanisms and Phytotherapeutic Intervention: A Systematic Review

Navrinder Kaur et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Article Cell Biology

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma

Yilan Song et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Neurosciences

The Evolving Dialogue of Microglia and Neurons in Alzheimer's Disease: Microglia as Necessary Transducers of Pathology

E. Simon et al.

NEUROSCIENCE (2019)

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Review Medicine, Research & Experimental

Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer's disease, Parkinson's disease

Sean Hong Tan et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Immunology

The benefits of neuroinflammation for the repair of the injured central nervous system

Heather Y. F. Yong et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

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Review Pharmacology & Pharmacy

An exploration of aptamer internalization mechanisms and their applications in drug delivery

Lin-Yan Wan et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Multidisciplinary Sciences

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

Takahiro Masuda et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Analyzing Secondary Structure Patterns in DNA Aptamers Identified via CompELS

Richard Sullivan et al.

MOLECULES (2019)

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Article Cell Biology

Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity

Mehmet Ilyas Cosacak et al.

CELL REPORTS (2019)

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Review Biochemistry & Molecular Biology

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology

Wei X. Huff et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Immunology

Toll-like receptors in the pathogenesis of neuroinflammation

V Kumar

JOURNAL OF NEUROIMMUNOLOGY (2019)

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Article Neurosciences

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F. Lloyd et al.

NATURE NEUROSCIENCE (2019)

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Editorial Material Clinical Neurology

Neuroinflammation - a common thread in neurological disorders

Nils Erik Gilhus et al.

NATURE REVIEWS NEUROLOGY (2019)

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Editorial Material Multidisciplinary Sciences

Targeting microglia in brain disorders

Josef Priller et al.

SCIENCE (2019)

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Article Medicine, Research & Experimental

Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson's Disease Model

Xiaoxi Ren et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Review Immunology

A General Introduction to Glucocorticoid Biology

Steven Timmermans et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Aptamer-Conjugated Framework Nucleic Acids for the Repair of Cerebral Ischemia-Reperfusion Injury

Shiyong Li et al.

NANO LETTERS (2019)

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Article Biochemistry & Molecular Biology

The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-β Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

Zhi-Man Liang et al.

NUCLEIC ACID THERAPEUTICS (2019)

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Review Pharmacology & Pharmacy

Heat-Shock Proteins in Neuroinflammation

Brigitta Dukay et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Pharmacology & Pharmacy

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

Leonardo Guzman-Martinez et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Inside the Black Box: What Makes SELEX Better?

Natalia Komarova et al.

MOLECULES (2019)

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Review Biochemistry & Molecular Biology

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

Sofie Voet et al.

TRENDS IN MOLECULAR MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Thermodynamic study of aptamers binding to their target proteins

Taiichi Sakamoto et al.

BIOCHIMIE (2018)

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Review Pharmacology & Pharmacy

Selective drug delivery approaches to lesioned brain through blood brain barrier disruption

Zahraa S. Al-Ahmady

EXPERT OPINION ON DRUG DELIVERY (2018)

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Review Immunology

Inflammation in CNS neurodegenerative diseases

Jodie Stephenson et al.

IMMUNOLOGY (2018)

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Article Biochemical Research Methods

Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases

Venkatanaidu Karri et al.

JOURNAL OF PROTEOMICS (2018)

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Article Neurosciences

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease

Srikant Rangaraju et al.

MOLECULAR NEURODEGENERATION (2018)

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Review Cell Biology

Mechanisms of clathrin-mediated endocytosis

Marko Kaksonen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Clinical Neurology

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Melanie D. Sweeney et al.

NATURE REVIEWS NEUROLOGY (2018)

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Article Geriatrics & Gerontology

Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models

Claudia Balducci et al.

NEUROBIOLOGY OF AGING (2018)

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Review Biochemistry & Molecular Biology

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors

Madhu Chaturvedi et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

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Article Geriatrics & Gerontology

NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

Caixia Zhang et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Review Pharmacology & Pharmacy

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

Bushra Shal et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Medicine, Research & Experimental

Novel DNA Aptamers for Parkinson's Disease Treatment Inhibit alpha-Synuclein Aggregation and Facilitate its Degradation

Yuan Zheng et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Article Medicine, Research & Experimental

A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo

Aaron Prodeus et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Review Pharmacology & Pharmacy

Aptamer-based targeted therapy

Guizhi Zhu et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Chemistry, Multidisciplinary

Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Denzil Furtado et al.

ADVANCED MATERIALS (2018)

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Review Biochemistry & Molecular Biology

SELEX methods on the road to protein targeting with nucleic acid aptamers

Payam Bayat et al.

BIOCHIMIE (2018)

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Review Neurosciences

Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention

Sara A. Ferreira et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Review Immunology

Damage-Associated Molecular Patterns in Inflammatory Diseases

Jong Seong Roh et al.

IMMUNE NETWORK (2018)

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Review Cell Biology

Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1

Bruno Alexandre Quadros Gomes et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Neurosciences

Role of Microglia TLRs in Neurodegeneration

Bernd L. Fiebich et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Review Pediatrics

Possible strategies to cross the blood-brain barrier

Cinzia M. Bellettato et al.

ITALIAN JOURNAL OF PEDIATRICS (2018)

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Review Chemistry, Medicinal

Potential Inherent Stimulation of the Innate Immune System by Nucleic Acid Aptamers and Possible Corrective Approaches

John G. Bruno

PHARMACEUTICALS (2018)

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Article Biochemistry & Molecular Biology

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation

Zijing Huang et al.

CELL DEATH AND DIFFERENTIATION (2018)

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Review Cell Biology

Aptamers Against Pro- and Anti-Inflammatory Cytokines: A Review

Maryam Boshtam et al.

INFLAMMATION (2017)

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Article Neurosciences

Neuroinflammation pathways: a general review

Tara Shabab et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2017)

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Review Neurosciences

Inflammatory Response in the CNS: Friend or Foe?

Marta Sochocka et al.

MOLECULAR NEUROBIOLOGY (2017)

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Review Biotechnology & Applied Microbiology

Aptamers as targeted therapeutics: current potential and challenges

Jiehua Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

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Review Immunology

Reactive Astrocytes: Production, Function, and Therapeutic Potential

Shane A. Liddelow et al.

IMMUNITY (2017)

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Review Biochemistry & Molecular Biology

Natalizumab in Multiple Sclerosis: Long-Term Management

Marinella Clerico et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Biochemistry & Molecular Biology

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Shuaijian Ni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Immunology

Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

Meetu Wadhwa et al.

JOURNAL OF NEUROINFLAMMATION (2017)

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Article Medicine, Research & Experimental

Immunostimulatory Properties of Lipid Modified CpG Oligonucleotides

Chunsong Yu et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Biochemistry & Molecular Biology

Rapid Complexation of Aptamers by Their Specific Antidotes

Heidi Stoll et al.

MOLECULES (2017)

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Review Neurosciences

Selective neuronal vulnerability in Parkinson disease

D. James Surmeier et al.

NATURE REVIEWS NEUROSCIENCE (2017)

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Review Neurosciences

Neuroimmunology of Traumatic Brain Injury: Time for a ParadigmShift

Yasir N. Jassam et al.

NEURON (2017)

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Article Multidisciplinary Sciences

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

Nirit Mor-Vaknin et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

The Lifespan and Turnover of Microglia in the Human Brain

Pedro Reu et al.

CELL REPORTS (2017)

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Article Cell Biology

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Katharine Askew et al.

CELL REPORTS (2017)

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Article Multidisciplinary Sciences

Assessment of Variability in the SOMAscan Assay

Julian Candia et al.

SCIENTIFIC REPORTS (2017)

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Review Immunology

Cytokine networks in neuroinflammation

Burkhard Becher et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Clinical Neurology

Molecular-based diagnosis of multiple sclerosis and its progressive stage

Christopher Barbour et al.

ANNALS OF NEUROLOGY (2017)

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Review Chemistry, Multidisciplinary

Amyloid beta: structure, biology and structure-based therapeutic development

Guo-fang Chen et al.

ACTA PHARMACOLOGICA SINICA (2017)

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Article Immunology

Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury

Xiaodong Yang et al.

BRAIN BEHAVIOR AND IMMUNITY (2017)

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Review Medicine, Research & Experimental

Delivery is key: lessons learnt from developing splice-switching antisense therapies

Caroline Godfrey et al.

EMBO MOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Development of a Bifunctional Aptamer Targeting the Transferrin Receptor and Epithelial Cell Adhesion Molecule (EpCAM) for the Treatment of Brain Cancer Metastases

Joanna Macdonald et al.

ACS CHEMICAL NEUROSCIENCE (2017)

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Article Clinical Neurology

Is amyloid-beta harmful to the brain? Insights from human imaging studies

William Jagust

BRAIN (2016)

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Review Neurosciences

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Yu Tang et al.

MOLECULAR NEUROBIOLOGY (2016)

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Review Chemistry, Analytical

Aptamers in analytics

Muslum Ilgu et al.

ANALYST (2016)

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Article Immunology

Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury

Siqi Zhao et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

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Review Pharmacology & Pharmacy

Long-term side effects of glucocorticoids

Merih Oray et al.

EXPERT OPINION ON DRUG SAFETY (2016)

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Article Biochemistry & Molecular Biology

Neuroinflammation: the devil is in the details

Damon J. DiSabato et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Article Immunology

New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies

T. Sehr et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Immunology

Brain trauma elicits non-canonical macrophage activation states

Charles C. Kim et al.

JOURNAL OF NEUROINFLAMMATION (2016)

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Article Medicine, General & Internal

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

A. Michael Lincoff et al.

LANCET (2016)

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Article Neurosciences

INHIBITION OF CEREBRAL VASCULAR INFLAMMATION BY BRAIN ENDOTHELIUM-TARGETED OLIGODEOXYNUCLEOTIDE COMPLEX

Jing Hu et al.

NEUROSCIENCE (2016)

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Review Clinical Neurology

Cytokine Therapies in Neurological Disease

Shila Azodi et al.

NEUROTHERAPEUTICS (2016)

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Article Multidisciplinary Sciences

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Michael J. D. Daniels et al.

NATURE COMMUNICATIONS (2016)

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Article Medicine, Research & Experimental

A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

Wei-Yun Lai et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2016)

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Article Multidisciplinary Sciences

Bioactivity of 2′-deoxyinosine-incorporated aptamer AS1411

Xinmeng Fan et al.

SCIENTIFIC REPORTS (2016)

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Review Biochemistry & Molecular Biology

Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy

Man Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Biochemical Research Methods

Aptamer-Drug Conjugates

Guizhi Zhu et al.

BIOCONJUGATE CHEMISTRY (2015)

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Article Clinical Neurology

Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial

Joseph Butchart et al.

NEUROLOGY (2015)

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Review Neurosciences

RNA Structures as Mediators of Neurological Diseases and as Drug Targets

Viachaslau Bernat et al.

NEURON (2015)

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Article Clinical Neurology

Neuroinflammation: Ways in Which the Immune System Affects the Brain

Richard M. Ransohoff et al.

NEUROTHERAPEUTICS (2015)

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Article Multidisciplinary Sciences

Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model

Huiyu Liang et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration

Shanshan Cheng et al.

SCIENTIFIC REPORTS (2015)

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Review Biochemistry & Molecular Biology

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

Mark D. Turner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

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Article Hematology

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

Julia Hoellenriegel et al.

BLOOD (2014)

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Review Nanoscience & Nanotechnology

Current approaches to enhance CNS delivery of drugs across the brain barriers

Cui-Tao Lu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

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Review Neurosciences

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

Zhiyou Cai et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2014)

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Article Oncology

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

Jonathan E. Rosenberg et al.

INVESTIGATIONAL NEW DRUGS (2014)

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Article Clinical Neurology

Stage-Dependent Nigral Neuronal Loss in Incidental Lewy Body and Parkinson's Disease

Anke A. Dijkstra et al.

MOVEMENT DISORDERS (2014)

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Article Biochemistry & Molecular Biology

Binding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognition

Tomohiko Hayashi et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Clinical Neurology

Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study

Danilo Zanotta et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2014)

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Article Medicine, Research & Experimental

Agonistic CD200R1 DNA Aptamers Are Potent Immunosuppressants That Prolong Allogeneic Skin Graft Survival

Aaron Prodeus et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2014)

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Review Clinical Neurology

The epigenetics of multiple sclerosis and other related disorders

Peter J. van den Elsen et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2014)

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Review Immunology

A comparative review of toll-like receptor 4 expression and functionality in different animal species

Celine Vaure et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

A Short DNA Aptamer That Recognizes TNFα and Blocks Its Activity in Vitro

Erik W. Orava et al.

ACS CHEMICAL BIOLOGY (2013)

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Article Clinical Neurology

Brain injury biomarkers are not dependent on -amyloid in normal elderly

David S. Knopman et al.

ANNALS OF NEUROLOGY (2013)

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Review Oncology

The role of Gliadel wafers in the treatment of high-grade gliomas

Amade Bregy et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2013)

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Article Biochemical Research Methods

In vitro selection of a DNA aptamer targeted against Shigella dysenteriae

Nuo Duan et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2013)

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Review Multidisciplinary Sciences

Microglia: Scapegoat, Saboteur, or Something Else?

Adriano Aguzzi et al.

SCIENCE (2013)

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Article Cell Biology

Minocycline selectively inhibits M1 polarization of microglia

K. Kobayashi et al.

CELL DEATH & DISEASE (2013)

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Article Medicine, Research & Experimental

In vivo SELEX for Identification of Brain-penetrating Aptamers

Congsheng Cheng et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2013)

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Article Biochemical Research Methods

Single-molecule atomic force microscopy on live cells compares aptamer and antibody rupture forces

Meghan B. O'Donoghue et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)

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Article Chemistry, Analytical

Selection of DNA Aptamers That Recognize α-Synuclein Oligomers Using a Competitive Screening Method

Kaori Tsukakoshi et al.

ANALYTICAL CHEMISTRY (2012)

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Article Gastroenterology & Hepatology

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

Christer Baeck et al.

GUT (2012)

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Review Clinical Neurology

Gene expression profiling in human neurodegenerative disease

Johnathan Cooper-Knock et al.

NATURE REVIEWS NEUROLOGY (2012)

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Review Clinical Neurology

Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies

Samuel E. Marsh et al.

ALZHEIMERS RESEARCH & THERAPY (2012)

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Article Medicine, Research & Experimental

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

Samantha E. Wilner et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2012)

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Review Biochemistry & Molecular Biology

Cell-SELEX Technology

Shoji Ohuchi

BIORESEARCH OPEN ACCESS (2012)

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Article Multidisciplinary Sciences

Bioavailability of resveratrol

Thomas Walle

RESVERATROL AND HEALTH (2011)

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Review Cell Biology

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

Agnes E. Coutinho et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

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Molecular mechanism and physiological functions of clathrin-mediated endocytosis

Harvey T. McMahon et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

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Review Biochemistry & Molecular Biology

Mechanisms Underlying Inflammation in Neurodegeneration

Christopher K. Glass et al.

CELL (2010)

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Review Immunology

Inflammation in neurodegenerative diseases

Sandra Amor et al.

IMMUNOLOGY (2010)

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Article Immunology

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Jin A. Shin et al.

JOURNAL OF NEUROIMMUNOLOGY (2010)

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The emerging field of RNA nanotechnology

Peixuan Guo

NATURE NANOTECHNOLOGY (2010)

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Structure and function of the blood-brain barrier

N. Joan Abbott et al.

NEUROBIOLOGY OF DISEASE (2010)

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

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Review Chemistry, Medicinal

Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation

Amy H. Moore et al.

PHARMACEUTICALS (2010)

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Review Chemistry, Medicinal

Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions

Maria Antonietta Ajmone-Cat et al.

PHARMACEUTICALS (2010)

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Review Pharmacology & Pharmacy

Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

Joerg Vollmer et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

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Review Biochemistry & Molecular Biology

Mechanisms of Endocytosis

Gary J. Doherty et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

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An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease

Bruno P. Imbimbo

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

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Review Clinical Neurology

Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?

Erin E. Longbrake et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2009)

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Article Biochemistry & Molecular Biology

Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses

Yi-Chung Chang et al.

FASEB JOURNAL (2009)

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Article Oncology

Molecular recognition of acute myeloid leukemia using aptamers

K. Sefah et al.

LEUKEMIA (2009)

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Article Medicine, Research & Experimental

Multivalent 4-1BB binding aptamers costimulate CD8(+) T cells and inhibit tumor growth in mice

James O. McNamara et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

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Article Biochemistry & Molecular Biology

Exploring TAR-RNA aptamer loop-loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance

Isabelle Lebars et al.

NUCLEIC ACIDS RESEARCH (2008)

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Article Multidisciplinary Sciences

Aptamer-based endocytosis of a lysosomal enzyme

Chi-hong B. Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Review Cell Biology

Glucocorticoids in the control of neuroinflammation

Denise Tischner et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2007)

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Article Clinical Neurology

Perispinal etanercept for treatment of Alzheimer's disease

Edward Tobinick

CURRENT ALZHEIMER RESEARCH (2007)

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Article Biochemistry & Molecular Biology

Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity:: role of tumor necrosis factor-α

K Sriram et al.

JOURNAL OF NEUROCHEMISTRY (2006)

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Article Neurosciences

Inhibitory effect of minocycline on amyloid β fibril formation and human microglial activation

A Familian et al.

GLIA (2006)

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Article Cell Biology

The LPS receptor, CD14 in experimental autoimmune encephalomyelitis and multiple sclerosis

S Walter et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2006)

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Article Chemistry, Multidisciplinary

Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain

J Kreuter

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2004)

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Article Chemistry, Multidisciplinary

Pharmacokinetics and biodistribution of novel aptamer compositions

JM Healy et al.

PHARMACEUTICAL RESEARCH (2004)

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Article Neurosciences

Expression of CD137 and its ligand in human neurons, astrocytes, and microglia: Modulation by FGF-2

C Reali et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

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Article Clinical Neurology

Broad expression of Toll-like receptors in the human central nervous system

M Bsibsi et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

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Review Multidisciplinary Sciences

Oxidants, oxidative stress and the biology of ageing

T Finkel et al.

NATURE (2000)

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Article Biochemistry & Molecular Biology

Tetracycline affects abnormal properties of synthetic PrP peptides and PrPSc in vitro

F Tagliavini et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

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