Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/ijms241914757
Keywords
solution blow spinning; electrospinning; nanofibers; biodegradable polymers; transdermal delivery; tissue engineering; 3D cell culture; regenerative medicine; biosensors; minimally invasive surgery
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Solution Blow Spinning (SBS) is a new technology for producing nano and microfibers of polymeric, nanocomposite, and ceramic materials. It offers advantages such as fast fiber generation and simplicity of experimental setup, making on-site production possible. In the field of biomedicine, SBS has been explored for applications such as drug delivery, 3D culturing, regenerative medicine, and biosensors, showing promising results.
In recent years, Solution Blow Spinning (SBS) has emerged as a new technology for the production of polymeric, nanocomposite, and ceramic materials in the form of nano and microfibers, with similar features to those achieved by other procedures. The advantages of SBS over other spinning methods are the fast generation of fibers and the simplicity of the experimental setup that opens up the possibility of their on-site production. While producing a large number of nanofibers in a short time is a crucial factor in large-scale manufacturing, in situ generation, for example, in the form of sprayable, multifunctional dressings, capable of releasing embedded active agents on wounded tissue, or their use in operating rooms to prevent hemostasis during surgical interventions, open a wide range of possibilities. The interest in this spinning technology is evident from the growing number of patents issued and articles published over the last few years. Our focus in this review is on the biomedicine-oriented applications of SBS for the production of nanofibers based on the collection of the most relevant scientific papers published to date. Drug delivery, 3D culturing, regenerative medicine, and fabrication of biosensors are some of the areas in which SBS has been explored, most frequently at the proof-of-concept level. The promising results obtained demonstrate the potential of this technology in the biomedical and pharmaceutical fields.
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