4.7 Article

Inhibition of Polyamine Catabolism Reduces Cellular Senescence

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Aging Hallmarks and the Role of Oxidative Stress

Edio Maldonado et al.

Summary: Aging is a complex biological process with a decline in physical function and increased risk of chronic diseases. Studies have identified nine hallmarks of aging, including telomere shortening, genomic instability, epigenetic modifications, mitochondrial dysfunction, loss of proteostasis, dysregulated nutrient sensing, stem cell exhaustion, cellular senescence, and altered cellular communication. Among these mechanisms, mitochondrial dysfunction and the resulting elevated reactive oxygen species (ROS) production play a crucial role in age-related damage and the aging phenotype.

ANTIOXIDANTS (2023)

Review Endocrinology & Metabolism

Targeting aging mechanisms: pharmacological perspectives

Alexey Moskalev et al.

Summary: Geroprotectors can impact the aging process through multiple mechanisms, such as antioxidant effects, regulation of protein homeostasis, suppression of genomic instability, modulation of epigenetics, and preservation of mitochondrial function.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2022)

Article Geriatrics & Gerontology

Characterization of cellular senescence in doxorubicin-induced aging mice

Tianyue Sun et al.

Summary: By studying a mouse model of doxorubicin-induced aging, we found that a dose of 5 mg/kg of doxorubicin was optimal for inducing cellular senescence in mice. This dose led to an increase in senescent cells and the accumulation of lipofuscin in the kidney and liver, respectively. These preliminary findings support the use of doxorubicin-induced aging mice as an animal model for evaluating potential anti-aging drug candidates.

EXPERIMENTAL GERONTOLOGY (2022)

Review Neurosciences

Aging and Alzheimer's disease connection: Nuclear Tau and lamin A

Laura Gil et al.

Summary: This review article focuses on critical molecular events in AD neurons that lead to the loss of plasticity underlying cognitive deficits. By studying the role of nuclear Tau in regulating chromatin structure and function during aging, as well as the cascade of events initiated by aberrant cell cycle reentry, the mechanisms underlying dysfunction in AD neurons are revealed.

NEUROSCIENCE LETTERS (2021)

Article Cell Biology

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction

YongTian Liang et al.

Summary: Mitochondrial function declines with age in the brain, and supplementing spermidine levels can delay this decline. The levels of hypusinated eIF5A decline with age in the Drosophila brain, but can be boosted by dietary spermidine. Attenuating eIF5A hypusination affects brain mitochondrial respiration and accelerates aging in locomotion and memory formation in adult Drosophilae, indicating it may be a potential diagnostic and therapeutic avenue for age-induced cognitive decline and neurodegeneration.

CELL REPORTS (2021)

Editorial Material Cell Biology

Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging

Sebastian J. Hofer et al.

Summary: Spermidine is a natural polyamine that plays a central role in promoting cellular autophagy, prolonging lifespan, and improving mitochondrial function. Dietary supplementation of spermidine enhances the hypusination of protein eEF5/EIF5A, boosts cerebral mitochondrial function and cognition.

AUTOPHAGY (2021)

Article Physiology

Age-related declines in muscle and respiratory function are proportionate to declines in performance in Master Track Cyclists

Pablo Duro Ocana et al.

Summary: Respiratory and musculoskeletal function decline with age regardless of physical activity levels, affecting performance in ageing cyclists. Reduced muscle function, specifically take-off velocity, is the major contributor to the decline in performance among ageing cyclists.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2021)

Editorial Material Cell Biology

Polyamines reverse immune senescence via the translational control of autophagy

Hanlin Zhang et al.

AUTOPHAGY (2020)

Article Biochemistry & Molecular Biology

Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs

Akihiko Sakamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Inhibition of dendritic spine extension through acrolein conjugation with α-, β-tubulin proteins

Takeshi Uemura et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

Review Cell Biology

Senescence and aging: Causes, consequences, and therapeutic avenues

Domhnall McHugh et al.

JOURNAL OF CELL BIOLOGY (2018)

Review Multidisciplinary Sciences

Facing up to the global challenges of ageing

Linda Partridge et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Acrolein toxicity at advanced age: present and future

Kazuei Igarashi et al.

AMINO ACIDS (2018)

Article Multidisciplinary Sciences

Spermine oxidase promotes bile canalicular lumen formation through acrolein production

Takeshi Uemura et al.

SCIENTIFIC REPORTS (2017)

Review Neurosciences

Ageing, metabolism and cardiovascular disease

Sarah Costantino et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Editorial Material Public, Environmental & Occupational Health

Stroke: a global response is needed

Walter Johnson et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2016)

Review Biochemistry & Molecular Biology

Functions of Polyamines in Mammals

Anthony E. Pegg

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Toxicology

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

Akshata Moghe et al.

TOXICOLOGICAL SCIENCES (2015)

Editorial Material Cell Biology

Spermidine-triggered autophagy ameliorates memory during aging

Stephan J. Sigrist et al.

AUTOPHAGY (2014)

Article Biochemistry & Molecular Biology

Inactivation of GAPDH as one mechanism of acrolein toxicity

Mizuho Nakamura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Cell Biology

Spermidine promotes mating and fertilization efficiency in model organisms

Maria Anna Bauer et al.

CELL CYCLE (2013)

Review Biochemistry & Molecular Biology

Spermine oxidase: ten years after

Manuela Cervelli et al.

AMINO ACIDS (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Review Cell Biology

Polyamines in aging and disease

Nadege Minois et al.

AGING-US (2011)

Article Multidisciplinary Sciences

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

Andrew C. Goodwin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Plant Sciences

The early history of polyamine research

Uriel Bachrach

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Polyamine catabolism and disease

Robert A. Casero et al.

BIOCHEMICAL JOURNAL (2009)

Review Endocrinology & Metabolism

Spermidine/spermine-N1-acetyltransferase:: a key metabolic regulator

Anthony E. Pegg

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

Article Biochemistry & Molecular Biology

Decrease in polyamines with aging and their ingestion from food and drink

K Nishimura et al.

JOURNAL OF BIOCHEMISTRY (2006)

Review Biochemistry & Molecular Biology

Polyamine modulon in Escherichia coli: Genes involved in the stimulation of cell growth by polyamines

K Igarashi et al.

JOURNAL OF BIOCHEMISTRY (2006)

Article Biochemistry & Molecular Biology

The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway

A Tanel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)

Article Biochemistry & Molecular Biology

Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine

N Qu et al.

BIOCHEMICAL JOURNAL (2003)

Article Biochemistry & Molecular Biology

Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients

K Sakata et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Biochemistry & Molecular Biology

Polyamine cytotoxicity in the presence of bovine serum amine oxidase

S Sharmin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Article Biochemistry & Molecular Biology

Polyamines: Mysterious modulators of cellular functions

K Igarashi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)