Differential Effects of the Processed and Unprocessed Garlic (Allium sativum L.) Ethanol Extracts on Neuritogenesis and Synaptogenesis in Rat Primary Hippocampal Neurons

Editorial Material Cell Biology

Brain-derived neurotrophic factor in main neurodegenerative diseases

Serena Camuso et al.

NEURAL REGENERATION RESEARCH (2023)

Article Plant Sciences

Mechanistic study of Coriandrum sativum on neuritogenesis and synaptogenesis based on computationally guided in vitro analyses

Yeasmin Akter Munni et al.

Summary: This study found that Coriandrum sativum extract can promote synaptogenesis and neuronal growth, potentially through the neurotrophin signaling pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Review Neurosciences

Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders

Ramin Ahangar-Sirous et al.

Summary: Age-related neurological disorders (ANDs), including Alzheimer's Disease and Parkinson's Disease, are characterized by inflammation, oxidative stress, and misfolded proteins accumulation. Garlic and aged garlic extract, known for their anti-inflammatory and antioxidant properties, have potential neuroprotective effects in treating ANDs.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2022)

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Review Biochemistry & Molecular Biology

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment

Muhammad Shahid Nadeem et al.

Summary: Allicin is a defense molecule produced by garlic cells, which has antioxidant and neuroprotective properties. It has potential therapeutic effects on various diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders.

ANTIOXIDANTS (2022)

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Article Chemistry, Medicinal

Unveiling the effect of Withania somnifera on neuronal cytoarchitecture and synaptogenesis: A combined in vitro and network pharmacology approach

Sarmistha Mitra et al.

Summary: This study explores the mechanism of action of Withania somnifera (WS) on neuritogenesis and finds that it promotes neuronal growth. Additionally, WS was observed to modulate the neurotrophin signaling pathway and steroidal lactones in WS might act as nerve growth factor (NGF)-mimetics. These findings suggest the potential of WS as a therapeutic agent for memory-related neurological disorders.

PHYTOTHERAPY RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Centella asiatica promotes early differentiation, axodendritic maturation and synaptic formation in primary hippocampal neurons

Md Abdul Hannan et al.

Summary: This study aimed to investigate the effects of Centella asiatica and its active component asiatic acid on various stages of neuronal polarity. The results showed that CAE enhanced neurite outgrowth, dendritic and axonal morphology, and facilitated synapse formation, indicating its neurotrophic function. Asiatic acid also promoted neurite outgrowth, but to a lesser extent compared to CAE.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Cell Biology

Linalool Alleviates Aβ42-Induced Neurodegeneration via Suppressing ROS Production and Inflammation in Fly and Rat Models of Alzheimer's Disease

Chunyu Yuan et al.

Summary: The study found that linalool can increase the survival rate of AD model flies, reduce A beta-induced apoptosis and neurodegeneration, as well as decrease oxidative stress and inflammatory responses in the brain.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Pharmacology & Pharmacy

Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

Chatrawee Duangjan et al.

Summary: The study demonstrates that Anacardium occidentale leaf extracts have neuroprotective effects and promote antioxidant defense in neuronal cells through the SIRT1/Nrf2 signaling pathway, as well as increase neurite outgrowth and Ten-4 expression. Knocking down Ten-4 expression abolishes the neuritogenesis properties, suggesting the therapeutic potential of the extracts against oxidative stress-induced toxicity in neurodegenerative diseases.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders

Katherine L. Marshall et al.

Summary: Nervous system disorders are common health issues that will continue to increase in frequency as the population ages. Dying-back axonopathy is a hallmark of many neurologic diseases, leading to axonal disconnection from targets and functional impairment. In some diseases, axons can regenerate or sprout in an attempt to reconnect with targets and restore synapse function.

NEURAL REGENERATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology