Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms241411708
Keywords
H; pylori; vonoprazan; bismuth; stool based-PCR; next generation sequencing; NGS
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Despite the global decline in prevalence, efforts are needed to optimize H. pylori treatment regimens due to increasing antibiotic resistance. Advancements in sequencing technology have helped broaden our understanding of molecular mechanisms behind resistance and facilitated testing of antibiotic susceptibility. Establishing routine antibiotic susceptibility surveillance programs and enforcing antibiotic stewardship are important for managing H. pylori in a sustainable manner.
Despite the declining trend of Helicobacter pylori (H. pylori) prevalence around the globe, ongoing efforts are still needed to optimize current and future regimens in view of the increasing antibiotic resistance. The resistance of H. pylori to different antibiotics is caused by different molecular mechanisms, and advancements in sequencing technology have come a far way in broadening our understanding and in facilitating the testing of antibiotic susceptibility to H. pylori. In this literature review, we give an overview of the molecular mechanisms behind resistance, as well as discuss and compare different antibiotic susceptibility tests based on the latest research. We also discuss the principles of antibiotic stewardship and compare the performance of empirical therapies based on up-to-date resistance patterns and susceptibility-guided therapies in providing effective H. pylori treatment. Studies and clinical guidelines should ensure that the treatment being tested or recommended can reliably achieve a pre-agreed acceptable level of eradication rate and take into account the variations in antibiotic resistance across populations. Local, regional and international organizations must work together to establish routine antibiotic susceptibility surveillance programs and enforce antibiotic stewardship in the treatment of H. pylori, so that it can be managed in a sustainable and efficient manner.
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