4.7 Article

Pd(0)-catalyzed chemoselective construction of spirocarbocycles via an alkyne insertion/β-naphthol dearomatization cascade

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 15, Pages 3061-3064

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09099c

Keywords

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Funding

  1. National Science Foundation of China [21222201, 21271147, 51202192]
  2. 1000 Youth Talents Plan
  3. Education Department of Shaanxi Provincial Government [2013JQ2024]

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A microwave-assisted Pd(0)-catalyzed alkyne migratory insertion/beta-naphthol dearomatization cascade process has been accomplished to access a variety of spirocyclic compounds bearing all-carbon quaternary stereogenic centers in high yields with excellent chemoselectivities.

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