Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 43, Pages 9034-9037Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01526j
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Funding
- Chicago Biomedical Consortium
- Searle Funds at The Chicago Community Trust
- NIH [5R01GM102489]
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Spinach RNA aptamer contains a G-quadruplex motif that serves as a platform for binding and fluorescence activation of a GFP-like fluorophore. Here we show that Pb2+ induces formation of Spinach's G-quadruplex and activates fluorescence with high selectivity and sensitivity. This device establishes the first example of an RNA-based sensor that provides a simple and inexpensive tool for Pb2+ detection.
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