Journal
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
Volume 74, Issue 4, Pages 532-543Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09637486.2023.2226369
Keywords
Low (poly)phenol diet; excretion of phenolics; UHPLC-HR-MS; presence and absence of a Colon; catecholamines; tyrosine; phenylalanine
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This study investigated the phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet. The results showed that the potential sources of these substances include endogenous catecholamines, surplus tyrosine and phenylalanine, and catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.
Phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet have been investigated. Urine was collected over a 12h fasting period after adherence to a low (poly)phenol diet for 36h. UHPLC-HR-MS quantified 77 phenolics. Some were present in the urine of both groups in similar trace amounts and others were excreted in higher amounts by participants with a colon indicating the involvement of the microbiota. Most were present in sub- or low-mu mol amounts, but hippuric acid dominated accounting on average for 60% of the total for both volunteer categories indicating significant production from sources other than non-nutrient dietary (poly)phenols. The potential origins of the phenolics associated with the low (poly)phenol diet, include endogenous catecholamines, surplus tyrosine and phenylalanine, and washout of catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.
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