4.7 Article

Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 1, Pages 125-128

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc07656g

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Funding

  1. ABC 973 [2013CB733700]
  2. NNSFC [21125104, 51373039]
  3. PIRTU [IRT1117]
  4. Shanghai Sci. Tech. Comm. [12XD1405900]

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Two fluorescent switchable diarylethene derivatives which exhibit high affinity for amyloid-beta aggregates with the increase of fluorescence intensity were reported. Moreover, the probes show excellent photochromic and anti-photobleaching properties both in vitro and in vivo.

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