Are antibiotics still relevant in acne? A review of the therapeutic conundrum

Antibiotics have constituted the mainstay of acne therapy despite acne being classified as an inflammatory disorder. The indiscriminate usage of antibiotics over the years has thus fueled the issue of antimicrobial resistance. Cutibacterium acnes (C. acnes) can acquire resistance due to chromosomal mutation or genetic acquisition. C. acnes can transfer resistance to other resident flora, complicating the management of skin and soft tissue infections. It can also transfer resistant strains to other body sites and to immunocompromised and elderly patients thus putting them at risk of serious infections. Recent studies have highlighted the physiologic role of C. acnes in maintaining the normal homeostasis of the skin microbiome. The role of Malassezia in causation of acne has piqued interest in recent times. The efficacy of antibiotics in acne is attributed to their para-antibiotic, anti-inflammatory action rather than antimicrobial action. Thus, usage of low-dose antibiotics and alternatives to antibiotics has been advocated. Some alternative therapies showing efficacy in acne are probiotics, oral zinc, precision therapy using succinic acid, bacteriophages, and anti-biofilm therapy like myrtacin, topical azelaic acid, and salicylic acid. Using isotretinoin in early stages of acne can reduce the incidence of scarring and alleviate the need for antibiotics. Thus, a gradual shift from antibiotics to alternative therapies in acne is the need of the hour.

Automated summary

Antibiotics have been widely used for acne treatment, but their indiscriminate usage has led to the problem of antimicrobial resistance. Cutibacterium acnes can develop resistance through mutation or genetic acquisition, and can transfer this resistance to other bacteria, complicating the management of skin and soft tissue infections. Recent studies have highlighted the role of C. acnes in maintaining the skin microbiome, and the role of Malassezia in causing acne has also drawn interest. The effectiveness of antibiotics in acne treatment is mainly attributed to their anti-inflammatory action rather than antimicrobial action, thus advocating for the use of low-dose antibiotics and alternative therapies.