Journal
MICROCIRCULATION
Volume 23, Issue 5, Pages 337-344Publisher
WILEY
DOI: 10.1111/micc.12257
Keywords
microcirculation; endothelium; laser Doppler; laser speckle; iontophoresis; postocclusive hyperemia; local thermal hyperemia; microdialysis; skin
Categories
Funding
- Pfizer
- Actelion
- GlaxoSmithKline
- Bioprojet
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Several noninvasive techniques have been developed using laser light interaction in the skin to explore the skin's microcirculation. Combined with laser Doppler or LSCI, reactivity tests are used to explore skin endothelial and neurovascular function in humans, including PORH, LTH, PIV, and iontophoresis of vasodilators. Recent advances in our comprehension of the physiological pathways underlying these reactivity tests have been possible through topical or intradermal delivery of drugs that produce elevated local concentrations. Skin microvascular function has also been proposed as a prognostic biomarker or for evaluating the effect of drugs. Comprehension of the physiological pathways, together with recent technological improvements in microcirculation imaging, has provided reliable and reproducible tools to study skin microcirculation.
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