Geographic, sex and socioeconomic disparities in esophageal cancer incidence in China: A population-based study

Geographic and sex differences in esophageal cancer have been reported in China, but data are lacking at the local level. We aimed to investigate geographic and sex disparities in esophageal cancer incidence among Chinese counties and whether county-level socioeconomic status was associated with these variations. We obtained esophageal cancer data from 2015 to 2017 for 782 counties from population-based cancer registries in China. We calculated age-standardized incidence rates and male-to-female incidence rate ratios (IRRs) by county. We performed hotspot analysis to identify geographical clusters. We used negative binomial regression models to analyze the association between incidence rates and county-level socioeconomic factors. There were significant geographic disparities in esophageal cancer incidence, with 8.1 times higher rate in the 90th-percentile county than in the 10th-percentile county (23.7 vs 2.9 per 100 000 person-years). Clusters of elevated rates were prominent across north-central China. Nationally, men had 2.9 times higher incidence of esophageal cancer than women. By county, the male-to-female IRRs ranged from 1.1 to 21.1. Clusters of high male-to-female IRRs were observed in northeast China. Rurality (IRR 1.16, 95% CI 1.10-1.22), per capita gross domestic product (IRR 0.95, 0.92-0.98) and percentage of people with a high school diploma (IRR 0.86, 0.84-0.87) in a county were significantly associated with esophageal cancer incidence. The male-to-female IRRs were higher in counties with higher socioeconomic status. Substantial differences in incidence rates and sex ratios of esophageal cancer exist between Chinese counties, and county-level socioeconomic status was associated with these variations. These findings may inform interventions to reduce these disparities. Although esophageal cancer incidence is high in China, evidence suggests that incidence varies considerably by region and sex. In this study, drawing on data from cancer registries representing 782 counties in China, the authors examined the distribution of esophageal cancer incidence by geography and sex and investigated possible associations with socioeconomic status. Significant differences were found in incidence rates and sex ratio of esophageal cancer across counties. Notably, clusters of high incidence were observed across north-central China, and elevated incidence rates were observed in counties with low socioeconomic status. The findings suggest etiologic heterogeneity of esophageal cancer within China.image

Automated summary

This study investigated the geographic and sex disparities in esophageal cancer incidence among various counties in China and found significant differences. The incidence was higher in the north-central region, and males had a 2.9 times higher incidence rate compared to females. County-level socioeconomic status was associated with esophageal cancer incidence. These findings are important for reducing disparities in esophageal cancer.