Polysaccharides from Oudemansiella radicata residues attenuate carbon tetrachloride-induced liver injury

The present work aimed to investigate the potential hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). Our results demonstrated that RPS showed significantly protective effects against carbon tetrachloride (CCl4)-induced liver injury, and the possible mechanisms may be related with the predominant bioactivities of RPS containing anti-oxidation by activating the Nrf2 signal pathways, anti-inflammation by inhibiting NF-kappa B signal pathways and reducing the release of inflammatory cytokines, anti-apoptosis by regulating Bcl-2/Bax pathway, and anti-fibrosis by inhibiting the expressions of TGF-beta 1, Hyp and alpha-SMA, respectively. These findings suggested that RPS, a typical beta-type glycosidic pyranose, could be used as a promising diet supplement or medication for the adjunctive treatment of hepatic diseases, and also contributed to promoting the recyclable utilization of mushroom residues.

Automated summary

The present study aimed to investigate the hepatoprotective effects of Oudemansiella radicata residues polysaccharides (RPS). The results demonstrated that RPS showed significant protection against carbon tetrachloride (CCl4)-induced liver injury. The possible mechanisms included anti-oxidation, anti-inflammation, anti-apoptosis, and anti-fibrosis effects. These findings suggested that RPS could be used as a promising diet supplement or medication for hepatic diseases.