In-depth occlusion of dentine tubules via the application of (poly-L-aspartic acid)-strontium and phosphate/fluoride to treat dentine hypersensitivity

Review Engineering, Multidisciplinary

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

Hardy Limeback et al.

Summary: Hydroxyapatite (HAP) added to oral care products is a more effective agent than fluoride in controlling dentin hypersensitivity and may be superior to other desensitizers.

BIOMIMETICS (2023)

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Review Dentistry, Oral Surgery & Medicine

Comparative efficacy of self-administered dentifrices for the management of dentine hypersensitivity-A systematic review and network meta-analysis

Alexander J. Pollard et al.

Summary: This systematic review with network meta-analysis evaluates the effectiveness of self-administered dentifrices for dentine hypersensitivity (DH) pain management. The results suggest that self-applied dentifrices containing formulations of stannous, potassium +/stannous, or arginine used twice daily can effectively reduce DH pain. However, standardised methodology guidelines are needed for improved DH clinical studies.

JOURNAL OF DENTISTRY (2023)

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Article Chemistry, Physical

The mechanism of dentine hypersensitivity: Stimuli-induced directional cation transport through dentinal tubules

Nuo Chen et al.

Summary: This study demonstrates that stimuli-induced directional cation transport, rather than fluid-flow, through dentinal tubules actually leads to dentine hypersensitivity. The research provides evidence that external stimuli (pressure, pH, and temperature) can induce ion currents through negatively charged dentinal tubules, triggering nerve impulses and causing dentine hypersensitivity. Blocking these tubules with cationic hydrogels can significantly reduce nerve action potentials, while anionic hydrogels enhance them, supporting the role of cation-flow in dentine hypersensitivity.

NANO RESEARCH (2023)

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Review Biotechnology & Applied Microbiology

The Effectiveness of Calcium Phosphates in the Treatment of Dentinal Hypersensitivity: A Systematic Review

Melanie Maillard et al.

Summary: This systematic review evaluates the ability of different formulations of calcium phosphate to reduce dentin hypersensitivity pain level in clinical studies. The results show that calcium phosphates have properties that reduce dentin hypersensitivity pain. The biomimetic and non-toxic characteristics of these materials make them a major asset in treating dentin hypersensitivity.

BIOENGINEERING-BASEL (2023)

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Article Chemistry, Multidisciplinary

Deep and compact dentinal tubule occlusion via biomimetic mineralization and mineral overgrowth

Zhuo Chen et al.

Summary: Combining biomimetic mineralization and mineral overgrowth effectively occludes dentinal tubules, forming a compact and deep mineral layer with mechanical and acid resistance, demonstrating the potential for treating dentin hypersensitivity with inexpensive, long-term, and efficient therapy.

NANOSCALE (2022)

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Article Dentistry, Oral Surgery & Medicine

Effectiveness of 38% Silver Diamine Fluoride in Reducing Dentine Hypersensitivity on Exposed Root Surface in Older Chinese Adults: Study Protocol for a Randomised Double-Blind Study

Alice Kit Ying Chan et al.

Summary: This study aims to evaluate the anti-hypersensitivity effect of silver diamine fluoride on older Chinese adults with dentine hypersensitivity due to an exposed root surface. A randomised double-blind clinical trial will be conducted with at least 148 Chinese older adults aged 65 or above recruited for the study.

DENTISTRY JOURNAL (2022)

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Article Dentistry, Oral Surgery & Medicine

Effectiveness and cytotoxicity of two desensitizing agents: a dentin permeability measurement and dentin barrier testing in vitro study

Ruodan Jiang et al.

Summary: This study evaluated the efficacy of two desensitizers on dentin specimen permeability and dentin barrier cytotoxicity. Results showed that both GLU and RD significantly reduced dentin permeability and occluded the dentinal tubules, but RD's remineralization potential was not fully realized after a short period of immersion. Additionally, GLU showed cytotoxicity, while RD was non-cytotoxic.

BMC ORAL HEALTH (2022)

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Review Dentistry, Oral Surgery & Medicine

Occlusion effects of bioactive glass and hydroxyapatite on dentinal tubules: a systematic review

S. Behzadi et al.

Summary: This study evaluated the occlusion effects of bioactive glass and hydroxyapatite on dental tubules. The results showed that both bioactive glass and hydroxyapatite had the potential efficacy in dentin tubule occlusion compared to the control.

CLINICAL ORAL INVESTIGATIONS (2022)

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Article Engineering, Biomedical

Quantitative assessment of dentine mineralization and tubule occlusion by NovaMin and stannous fluoride using serial block face scanning electron microscopy

Behrad Mahmoodi et al.

Summary: The study evaluated the impact of NovaMin and stannous fluoride (SnF2) on dentine tubule occlusion using serial block-face SEM (SBF-SEM). Results showed that NovaMin achieved better occlusion than SnF2, leading to increased mineral density and dentine mineralization. SBF-SEM demonstrates potential for high-resolution analysis of bone-like materials for research and development of new biomaterials.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Article Nanoscience & Nanotechnology

Anti-Acid Biomimetic Dentine Remineralization Using Inorganic Silica Stabilized Nanoparticles Distributed Electronspun Nanofibrous Mats

Chuanzi Liu et al.

Summary: The study developed a Si/Ca(Sr)-NCF mat with acid resistant and biomimetic mineralizational nanoparticles, demonstrating its potential for dentine remineralization with antibacterial and cytocompatible properties.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Chemistry, Multidisciplinary

Chemical Aspects of Human and Environmental Overload with Fluorine

Jianlin Han et al.

Summary: This comprehensive review focuses on the effects of fluoride ions and organofluorine compounds on human health and the environment, as well as related topics including the reasons for the advancement of fluorine-containing pharmaceuticals and agrochemicals, metabolism of fluorinated drugs, withdrawn fluorinated drugs, natural sources of fluorine compounds in the environment, sources of fluoride intake, and biomarkers of fluoride exposure.

CHEMICAL REVIEWS (2021)

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Review Dentistry, Oral Surgery & Medicine