Journal
MICROCHIMICA ACTA
Volume 183, Issue 11, Pages 2925-2932Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-016-1940-2
Keywords
Electroanalysis; Differential pulse voltammetry; Ionic liquid; Layer-by-layer assembly; Nanomaterial; Cancer diagnosis; Indole-6-carboxylic acid
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Funding
- National Natural Science Foundation of China [51373089]
- NSF of Shandong [ZR2011BM003]
- Specialized Research Fund for the Doctoral Program of Higher Education [20123719120006]
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We describe a label-free electrochemical immunosensor for the carcinoembryonic antigen (CEA). It is based on a nanocomposite consisting of electrochemically reduced graphene oxide, gold nanoparticles (AuNPs), and poly(indole-6-carboxylic acid). Coupled to nanoparticle-amplification techniques and modified with ionic liquid (IL), this immunoassay shows high sensitivity and good selectivity for CEA. At the best working voltage of 0.95 V (vs. Ag/AgCl), the lower detection limit is 0.02 ng center dot mL(-1), and the response to CEA is linear in the range from 0.02 to 90 ng center dot mL(-1). The method was applied to the determination of CEA in spiked serum samples and gave recoveries in the range from 98.5 % to 102 %.
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