4.7 Article

Human RNase 1 can extensively oligomerize through 3D domain swapping thanks to the crucial contribution of its C-terminus

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The crystal structure of the domain-swapped dimer of onconase highlights some catalytic and antitumor activity features of the enzyme

Giovanni Gotte et al.

Summary: ONC is a monomeric amphibian pancreatic-type RNase with remarkable anticancer activity that can form a dimer (ONC-D) which retains catalytic activity and displays antitumor effects in melanoma cell lines by inhibiting the expression of Bcl2 and STAT-3. The study reveals the unexpected variability in quaternary assembly and open interface arrangement upon domain swapping, providing insights into the differences in biological activities of ONC and ONC-D.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases

Sabrina Fasoli et al.

Summary: Human Angiogenin (hANG) is a protein that promotes vessel formation and is associated with diseases like PD and ALS. Research shows that ANG can form enzymatically active dimers through three-dimensional domain swapping, which could be crucial in understanding its role in neurodegenerative pathologies in the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells

Alice Raineri et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera

Luciana Esposito et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Biochemistry & Molecular Biology

Consequences of the Endogenous N-Glycosylation of Human Ribonuclease 1

Valerie T. Ressler et al.

BIOCHEMISTRY (2019)

Article Biochemistry & Molecular Biology

A ribonuclease inhibitor resistant dimer of human pancreatic ribonuclease displays specific antitumor activity

Ayush Attery et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Biochemistry & Molecular Biology

Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner

Claudia Fiorini et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Platinated oligomers of bovine pancreatic ribonuclease: Structure and stability

Delia Picone et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles

Jo E. Lomax et al.

JOURNAL OF MOLECULAR BIOLOGY (2014)

Article Biochemistry & Molecular Biology

RNase A oligomerization through 3D domain swapping is favoured by a residue located far from the swapping domains

Francesca Vottariello et al.

BIOCHIMIE (2011)

Article Biochemistry & Molecular Biology

Impact of the C-terminal Disulfide Bond on the Folding and Stability of Onconase

Cindy Schulenburg et al.

CHEMBIOCHEM (2010)

Article Chemistry, Multidisciplinary

NMR Spectroscopy Reveals that RNase A is Chiefly Denatured in 40% Acetic Acid: Implications for Oligomer Formation by 3D Domain Swapping

Jorge Pedro Lopez-Alonso et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Biochemistry & Molecular Biology

Kinetic analysis provides insight into the mechanism of Ribonuclease A oligomer formation

Jorge P. Lopez-Alonso et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)

Article Biochemistry & Molecular Biology

Interaction of onconase with the human ribonuclease inhibitor protein

Rebecca F. Turcotte et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Review Biochemistry & Molecular Biology

A novel biological actions acquired by ribonuclease through oligomerization

M. Libonati et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2008)

Review Biochemistry & Molecular Biology

Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity

Thomas J. Rutkoski et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2008)

Review Biochemistry & Molecular Biology

Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes

W. Ardelt et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2008)

Article Biochemistry & Molecular Biology

Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein

R. Jeremy Johnson et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Deposition diseases and 3D domain swapping

Melanie J. Bennett et al.

STRUCTURE (2006)

Article Biochemistry & Molecular Biology

Formation, structure, and dissociation of the ribonuclease S three-dimensional domain-swapped dimer

JP López-Alonso et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biophysics

Dynamic properties of the N-terminal swapped dimer of ribonuclease A

A Merlino et al.

BIOPHYSICAL JOURNAL (2004)

Article Biochemistry & Molecular Biology

Oligomerization of ribonuclease A - Two novel three-dimensional domain-swapped tetramers

G Gotte et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Oligomerization of bovine ribonuclease A: structural and functional features of its multimers

M Libonati et al.

BIOCHEMICAL JOURNAL (2004)

Review Biochemistry & Molecular Biology

Cytotoxic ribonucleases: molecular weapons and their targets

AA Makarov et al.

FEBS LETTERS (2003)

Review Biochemistry & Molecular Biology

The unfolding story of three-dimensional domain swapping

F Rousseau et al.

STRUCTURE (2003)

Article Biochemistry & Molecular Biology

Structures of the two 3D domain-swapped RNase A trimers

YS Liu et al.

PROTEIN SCIENCE (2002)

Article Biochemistry & Molecular Biology

Stabilization of human pancreatic ribonuclease through mutation at its N-terminal edge

A Benito et al.

PROTEIN ENGINEERING (2002)

Review Biochemistry & Molecular Biology

3D domain swapping: As domains continue to swap

Y Liu et al.

PROTEIN SCIENCE (2002)

Article Biochemistry & Molecular Biology

Endowing human pancreatic ribonuclease with toxicity for cancer cells

PA Leland et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Structural properties of trimers and tetramers of ribonuclease A

A Nenci et al.

PROTEIN SCIENCE (2001)

Article Biochemistry & Molecular Biology

Contribution of chain termini to the conformational stability and biological activity of onconase

E Notomista et al.

BIOCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

A domain-swapped RNase A dimer with implications for amyloid formation

YS Liu et al.

NATURE STRUCTURAL BIOLOGY (2001)

Article Biochemistry & Molecular Biology

In vitro evolution of a dimeric variant of human pancreatic ribonuclease

N Russo et al.

BIOCHEMISTRY (2000)