Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 242, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.125136
Keywords
Co-spinning agents; Electrospinning; Nanofibers; Surface modification; Quaternized chitosan
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This article summarizes the importance of chitosan and its derivatives in industrial production, and focuses on the application and advantages of quaternized chitosan in the preparation of nanofibers. This combination not only enhances the properties of chitosan, but also imparts water solubility, expanding its wider range of applications, including wound dressings, air and water filters, drug delivery scaffolds, antimicrobial textiles, energy storage systems, and alkaline fuel cells.
The industrial production of chitosan, initiated over 50 years ago, has transformed its application across diverse industries, agriculture, and medicine. To enhance its properties, numerous chitosan derivatives have been syn-thesized. The quaternization of chitosan has proven beneficial, as it not only enhances its properties but also imparts water solubility, expanding its potential for a wider range of applications. Specifically, the utilization of quaternized chitosan-based nanofibers has leveraged the synergistic benefits of quaternized chitosan (including hydrophilicity, bioadhesiveness, antimicrobial, antioxidant, hemostatic, and antiviral activities, as well as ionic conductivity) in combination with the distinctive characteristics of nanofibers (such as a high aspect ratio and 3D architecture). This combination has permitted numerous possibilities, spanning from wound dressings, air and water filters, drug delivery scaffolds, antimicrobial textiles, to energy storage systems and alkaline fuel cells. In this comprehensive review, we examine the preparation methods, properties, and applications of various com-posite fibers containing quaternized chitosan. The advantages and disadvantages of each method and compo-sition are meticulously summarized, while relevant diagrams and figures illustrate the key findings.
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