Limonin, a novel AMPK activator, protects against LPS-induced acute lung injury

Review Emergency Medicine

Acute Respiratory Distress Syndrome

Alin Gragossian et al.

EMERGENCY MEDICINE CLINICS OF NORTH AMERICA (2022)

Article Biochemistry & Molecular Biology

Limonin relieves TGF-β-induced hepatocyte EMT and hepatic stellate cell activation in vitro and CCl4-induced liver fibrosis in mice via upregulating Smad7 and subsequent suppression of TGF-β/Smad cascade

Guangwen Shu et al.

Summary: Limonin inhibits TGF-beta-induced EMT of hepatocytes and activation of HSCs in vitro and alleviates mouse CCl4-induced liver fibrosis by upregulating Smad7.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

A novel mechanism for the protection against acute lung injury by melatonin: mitochondrial quality control of lung epithelial cells is preserved through SIRT3-dependent deacetylation of SOD2

Ning Li et al.

Summary: The mitochondrial quality control of lung epithelial cells is disrupted during sepsis, leading to abnormal mitochondrial function and acute lung injury. Melatonin has shown beneficial effects in sepsis and cardiopulmonary disease due to its antioxidative actions. This study explores the potential roles and molecular basis of melatonin in LPS-treated lung epithelial cells, and finds that melatonin can protect against sepsis-induced acute lung injury by preserving mitochondrial quality control in a SIRT3-dependent manner.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Review Pharmacology & Pharmacy

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Yu-Qiong He et al.

Summary: ALI and ARDS are common life-threatening lung diseases with high mortality rates, but there is still a lack of effective pharmacological therapies. Developing new drugs for therapy of ALI/ARDS is in great demand, as natural compounds have shown potential therapeutic effects and may also be helpful for treatment of COVID-19.

PHARMACOLOGICAL RESEARCH (2021)

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Article Immunology

Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis

Ya-Xian Wu et al.

Summary: The study found that Sophoricoside (SOP) can attenuate LPS-induced acute lung injury (ALI) through modulation of the AMPK/Nrf2 signaling pathway. This suggests that SOP may be a potential therapeutic candidate for treating ALI/ARDS.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Agriculture, Multidisciplinary

Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway

Runyu Yang et al.

Summary: Limonin can protect against LPS-induced liver injury by inhibiting pyroptosis signaling pathway.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

A review on the role of chemokines in the pathogenesis of systemic lupus erythematosus

Soudeh Ghafouri-Fard et al.

Summary: Chemokines, a group of low molecular weight cytokines, play important roles in the pathogenesis of systemic lupus erythematosus (SLE) and related complications such as lupus nephritis. Some members of the chemokine family have been more clearly defined in their roles in SLE patients or animal models of the disorder.

CYTOKINE (2021)

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Article Cell Biology

Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2

Jie Jin et al.

Summary: The study found that limonin can alleviate symptoms of arthritis by activating the Nrf2/HO1/NF-kappa B pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Oncology

Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of septic shock associated with acute renal injury

Hui An et al.

Summary: In this study, we compared the therapeutic effects of Angiotensin II (ANG II) and Norepinephrine (NE) on septic acute kidney injury (AKI) in rats induced by cecal ligation and puncture (CLP). The results showed that compared to NE, ANG II was more effective in alleviating CLP-induced septic AKI by restoring renal function and reducing mitochondrial damage.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Respiratory System

AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1

Israr Ahmad et al.

Summary: The study demonstrated that AICAR exerts protective effects in lung injury post exposure to bromine gas by upregulating lung HO-1 levels.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Biochemistry & Molecular Biology