Can old drugs learn new tricks? Achieving registration and public subsidy listing for off-patent medicines with novel therapeutic applications

Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

Review Clinical Neurology

Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis

Anees Bahji et al.

Summary: The study showed that intravenous racemic ketamine was more effective and better tolerated than intranasal esketamine for the treatment of unipolar and bipolar major depression.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Review Multidisciplinary Sciences

The extent to which off-patent registered prescription medicines are used for off-label indications in Australia: A scoping review

Katrina Howe et al.

Summary: The extent of off-patent prescription medicine use beyond registered indications in clinical settings in Australia is greater than previously reported. Variability in usage and funded availability of certain medication/off-label indication dyads exists across Australia. These findings highlight the two-tiered system of medicines regulation in Australia and its impact on equity of access to medicines.

PLOS ONE (2021)

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Review Cell Biology

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

C. Glenn Begley et al.

Summary: Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines, but insufficient consideration by academic researchers of the required processes may hinder its success. Critical factors for successful repurposed medicines include financial, intellectual property, and clinical considerations.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Editorial Material Medicine, General & Internal