Journal
INORGANICA CHIMICA ACTA
Volume 560, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2023.121818
Keywords
Copper(I) complexes; Pyrazoline; Metallodrugs
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Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE /thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. Accordingly, the X-ray studies the three prepared complexes belong to the monoclinic crystalline system. All complexes 1, 2, and 3 possess similar structural behavior around the Copper(I) atoms which presented a distorted tetrahedral coordination geometry determined by using the tau 4 (tau four) parameter analysis. The complete characterization of the prepared compounds also included HRMS-ESI(+), NMR and elemental analyses, MID infrared, and UV-Vis spectroscopies. TD-DFT studies were also performed to support the assignments and interpretation of the main absorption bands observed in the UV-Vis experiments. The binuclear CuI complexes were assayed against a panel of antibiotic-resistant (MDR) bacteria (S. aureus) and S. pseudointermedius (MDR isolated from dog skin) showing promising MIC (7.8 to 62.5 mu g/mL) and MBC (15.6 to 62.5 mu g/mL) values. Additionally, the binuclear complexes were also tested as anticancer agents against tumoral cells B16F10 and 4 T1 (metastatic murine melanoma and murine mammary carcinoma respectively) showing very low IC50 (0.16 to 0.6 mu M) values.
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