Electrocatalytic sensing of metronidazole by R-type hexagonal nanoferrites modified electrode

The current study was aimed to synthesize the R-type hexagonal nanoferrites (SrSn2Fe4O11) for electrochemical sensing of metronidazole (MN) in pharmaceutical and human specimen. The SrSn2Fe4O11 were prepared by sol-gel auto ignition method followed by structural and surface characterization by X-Ray diffraction (XRD) and atomic force microscopy (AFM) respectively. The resulting surface characterization data suggested that the synthesized SrSn2Fe4O11 have a single-phase crystalline structure with a crystalline size of 34.451 nm with surface topographical ranging from 0.506 to 3.37 nm. The SrSn2Fe4O11 modified glassy carbon electrode (SrSn2Fe4O11/GCE) was fabricated by a drop-casting method. The fabricated SrSn2Fe4O11/GCE was successfully applied for detecting MN in a phosphate buffer (PB) at pH-6, followed by a linear voltammetric response with the coefficient of determination (R2 = 0.998). The limit of detection and quantification (LOD/LOQ) for sensing MN was found to be 0.011 to 0.036 mu M, respectively. A differential pulse voltammetric study of MN on SrSn2Fe4O11/ GCE demonstrated a significant selectivity with RSD 2.0%. The proposed electrochemical method was success-fully applied for the quantitative detection of MN in pharmaceutical preparations and biological specimen.

Automated summary

The aim of this study was to synthesize R-type hexagonal nanoferrites (SrSn2Fe4O11) for electrochemical sensing of metronidazole (MN) in pharmaceutical and human specimen. The SrSn2Fe4O11 were prepared by sol-gel auto ignition method followed by structural and surface characterization using X-Ray diffraction (XRD) and atomic force microscopy (AFM) respectively. The synthesized SrSn2Fe4O11 had a single-phase crystalline structure with a crystalline size of 34.451 nm and surface topography ranging from 0.506 to 3.37 nm. A glassy carbon electrode modified with SrSn2Fe4O11 (SrSn2Fe4O11/GCE) was fabricated using a drop-casting method. The SrSn2Fe4O11/GCE showed successful detection of MN in a phosphate buffer at pH-6, with a linear voltammetric response (R2 = 0.998) and a limit of detection and quantification (LOD/LOQ) for MN ranging from 0.011 to 0.036 mu M. A differential pulse voltammetric study demonstrated significant selectivity for MN on the SrSn2Fe4O11/GCE with a RSD of 2.0%. The proposed electrochemical method was successfully applied for the quantitative detection of MN in pharmaceutical preparations and biological specimens.