4.4 Article

Intraoperative tissue sampling for histology in chronic osteomyelitis shows high neutrophil infiltration centrally and low remains in debrided presumed infection-free regions

Related references

Note: Only part of the references are listed.
Article Critical Care Medicine

Bone regeneration after marginal bone resection in two-stage treatment of chronic long bone infection- a combined histopathological and clinical pilot study

Gongteng Wang et al.

Summary: Marginal bone resection combined with local and systemic antibiotic therapy is an effective treatment option for chronic long bone infection, showing good bone regeneration potential and improved bone healing parameters. Despite a revision rate of 44.4%, the technique avoids large bone defects and revisions can be done by further marginal debridements.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2022)

Article Cell & Tissue Engineering

The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection

Y. Cai et al.

Summary: This study aimed to investigate the role of Staphylococcus aureus small colony variants (SCVs) in intraosseous invasion and colonization in patients with periprosthetic joint infection (PJI). The results showed that SCVs have a greater ability to invade and colonize bone, and there are significant differences in gene expression profiles between chronic and acute PJI. These findings are important for understanding the pathogenesis of chronic infections.

BONE & JOINT RESEARCH (2022)

Article Cell & Tissue Engineering

Diagnostic accuracy of neutrophil counts in histopathological tissue analysis in periprosthetic joint infection using the ICM, IDSA, and EBJIS criteria

I. K. Sigmund et al.

Summary: Histopathological analysis with different thresholds of polymorphonuclear neutrophils can assist in diagnosing periprosthetic joint infections, with a recommended threshold of >= 10 PMN/HPF for IDSA and ICM criteria to achieve optimal sensitivity and specificity. Furthermore, the performance of histopathological analysis varies between different types of joint replacement surgeries.

BONE & JOINT RESEARCH (2021)

Article Surgery

One-stage treatment of chronic osteomyelitis with an antibiotic-loaded biocomposite and a local or free flap

Anne Kathrine Lorentzen et al.

Summary: This study reports the outcomes of patients with chronic osteomyelitis (OM) treated by plastic and orthopedic surgeons with a one-stage operation using an antibiotic-loaded biocomposite (ALB) and local or free flaps. The results showed that 81.8% of patients healed uneventfully after the one-stage surgical intervention, while 18.2% experienced partial or complete flap necrosis requiring additional surgery.

EUROPEAN JOURNAL OF PLASTIC SURGERY (2021)

Article Orthopedics

Diagnosing Fracture-Related Infection: Current Concepts and Recommendations

Geertje A. M. Govaert et al.

JOURNAL OF ORTHOPAEDIC TRAUMA (2020)

Article Orthopedics

General treatment principles for fracture-related infection: recommendations from an international expert group

Willem-Jan Metsemakers et al.

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY (2020)

Review Orthopedics

Impact of Bacterial Infections on Osteogenesis: Evidence From In Vivo Studies

Michiel Croes et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2019)

Article Orthopedics

The value of quantitative histology in the diagnosis of fracture-related infection

M. Morgenstern et al.

BONE & JOINT JOURNAL (2018)

Article Orthopedics

Chronic osteomyelitis: what the surgeon needs to know

Michalis Panteli et al.

EFORT OPEN REVIEWS (2016)

Article Cell & Tissue Engineering

THE CRUCIAL ROLE OF NEUTROPHIL GRANULOCYTES IN BONE FRACTURE HEALING

A. Kovtun et al.

EUROPEAN CELLS & MATERIALS (2016)

Review Immunology

The role of bacterial biofilms in chronic infections

Thomas Bjarnsholt

APMIS (2013)

Review Cell & Tissue Engineering

Harnessing and Modulating Inflammation in Strategies for Bone Regeneration

Paschalia M. Mountziaris et al.

TISSUE ENGINEERING PART B-REVIEWS (2011)

Review Oncology

Cellular and molecular mechanisms of fibrosis

T. A. Wynn

JOURNAL OF PATHOLOGY (2008)