Journal
INFLAMMATORY BOWEL DISEASES
Volume -, Issue -, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izad231
Keywords
de novo Crohn's disease; ileal pouch; IPAA; pediatric inflammatory bowel disease; pouchitis
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This retrospective study highlights the challenges and opportunities of characterizing ileal pouch in children who develop de novo CD after IPAA surgery.
Children who undergo ileal pouch anal anastomosis (IPAA) surgery for refractory ulcerative colitis (UC) may ultimately develop a Crohn's disease (CD) phenotype. This de novo CD is open to broad interpretation and misattribution, and its manifestation in children is poorly understood. The surgically altered environment of the ileal pouch is at risk of a spectrum of ileal pouch disorders, which have limited description in children. In this issue of Inflammatory Bowel Diseases, a multicenter, retrospective study of children with UC who underwent IPAA and developed de novo CD highlights the challenges and opportunities of ileal pouch characterization in children.
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