Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 28, Pages 6039-6049Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc10327k
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Funding
- National Natural Science Foundation of China [21320102002]
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Tertiary enamides have long been thought of as stable and marginally valuable enamine variants in synthesis. This notion has been challenged, however, in recent years. Enabling the regulation of the cross-conjugation system of the tertiary enamides has been successfully shown to enhance delocalization of the nitrogen lone-pair electrons into a carbon-carbon double, thereby reinvigorating the enaminic reactivity of the tertiary enamides. In this article, I summarize the recent advances in the exploration of the nucleophilic reactions of tertiary enamides and their applications in the synthesis of natural products and heterocyclic compounds of biological and pharmaceutical relevance, with a primary focus on our own work.
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