Skin-protective effect of polysaccharide from ultrasonicated sesame oil cake

Research on the applications of sesame oil cake, a by-product of sesame oil manufacturing, as food additives and functional materials is ongoing. Herein, polysaccharides were extracted from sesame oil cake, and their components were analyzed to verify their skin-protective functions. An ultrasound system was utilized to extract the target analytes from sesame oil cake, and the polysaccharide fractions (CPS) were prepared through gradient ethanol precipitation. The polysaccharide extracts contained mannose, glucose, galactose, and arabinose, and their molecular weight decreased from 191 to 0.1 kDa with increasing ethanol concentration. When UV, LPS, and H2O2-induced HaCaT cells were treated with fractions CPS3 and CPS4 (400 & mu;g/mL), a significant reduction in the levels of tumor necrosis factor-alpha, interleukin-6, and reactive oxygen species was observed. Additionally, treatment of B16-F10 cells with CPS1 and CPS2 (400 & mu;g/mL) led to a significant decrease in melanin level and tyrosinase activity. These findings confirm that low-molecular-weight polysaccharides containing mannose and exhibiting skin-whitening and antioxidant effects can be obtained through ultrasonic treatment.

Automated summary

Research has shown that low-molecular-weight polysaccharides containing mannose can be extracted from sesame oil cake using ultrasound treatment. These polysaccharides exhibit skin-protective functions and can be used as food additives and functional materials.