Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 43, Pages 8946-8949Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02749g
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A novel, three-component C-C, C-N and C-O bond forming reaction is described. In the presence of 20 mol% CuO, this condensation reaction of CF3CHN2, nitriles, and aldehydes proceeds to afford CF3-substituted oxazolines in moderate to high yields with excellent diastereoselectivities. Subsequent ring-opening of oxazolines gives rise to the corresponding vicinal amino alcohols.
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