Journal
MICROBIAL PATHOGENESIS
Volume 101, Issue -, Pages 56-67Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2016.10.028
Keywords
MRSA; Antimicrobial resistance; SCCmec; Mobile genetic element; SCCmec typing
Categories
Funding
- National 973-Plan of China [2012CB720800]
- National Natural Science Foundation of China [31201362, 31101278]
- International Science & Technology Cooperation Program [2013B051000014]
- National Outstanding Doctoral Dissertation Funding [201459]
- Guangdong Outstanding Doctoral Dissertation Funding [K3140030]
- Open Project Program of State Key Laboratory of Food Science and Technology, Jiangnan University [SKLF-KF-201513]
- Open Project Program of Key Laboratory for Green Chemical Process of Ministry of Education in Wuhan Institute of Technology [GCP201506]
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Considered to be a potential superbug, methicillin-resistant Staphylococcus aureus (MRSA) has been one of the major recent infectious pathogens and thus poses a challenge to hospital infection control. The mobile genetic element staphylococcal chromosomal cassette mec (SCCmec) carries both the mecA or mecC gene, encoding for a novel specific penicillin-binding protein (PBP2a), and site-specific recombinase genes ccrAB orfand ccrC. In MRSA, the acquisition of SCCmec leads to the resistance to the beta-lactam antibiotics. As SCCmec plays a core role in the antimicrobial resistance characteristics, molecular epidemiology and evolution of MRSA, a thorough summary and comprehensive understanding of the prevalence and structural characteristics of SCCmec may aid in global surveillance, implementation and investigation on MRSA isolates, as well as further development of preventive and therapeutic approaches. Consequently, this review is aimed at describing the history, prevalence, types and subtypes, and current typing methods of SCCmec, with the focus on the typical structures of the SCCmec cassette. (C) 2016 Elsevier Ltd. All rights reserved.
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