Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 96, Pages 17124-17127Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc06628j
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- Japan Society for the Promotion of Science (JSPS) through the 'Funding Program for Next Generation World-Leading Researchers (NEXT Program)
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In vivo fluorescence imaging of beta-amyloid (A beta) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We synthesized novel push-pull dimethylaminothiophenyl (DTM) derivatives and evaluated their utility as in vivo fluorescence imaging probes targeting A beta plaques. As a result, we found that DTM-2 is a promising fluorescent probe for A beta plaques in the AD brains.
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