Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 14, Pages 2976-2979Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09685a
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Funding
- National Natural Science Foundation of China [21174060]
- Fundamental Research Funds for the Central Universities [1116020509]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1252]
- China Equipment and Education Resources System [CERS-1-45]
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A multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core-shell nanoparticles. The nanocarrier has good bio-compatibility and high transfection efficiency over the most popular transfection reagent, Lipofectamine 2000. Fluorescence resonance energy transfer within the nanocarrier provides a non-invasive and label-free method to track the intracellular release of siRNA.
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