Journal
MICROBIAL PATHOGENESIS
Volume 97, Issue -, Pages 119-124Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2016.05.016
Keywords
Glycerol monolaurate; Nanocapsules; Anti-biofilm; Kinetic; Candida albicans
Categories
Funding
- PPGPE/Centro Universitario Franciscano-Probic
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- FAPERGS (Fundacao de Amparo a Pesquisa do Rio Grande do Sul)
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Candida albicans does not only occur in the free living planktonic form but also grows in surface-attached biofilm communities. Moreover, these biofilms appear to be the most common lifestyle and are involved in the majority of human Candida infections. Nanoparticles can be used as an alternative to conventional antimicrobial agents and can also act as carriers for antibiotics and other drugs. In view of this, the aim of the study was develop, characterize and verify the anti-biofilm potential of GML Nanocapsules against C albicans. The GML Nanocapsules showed mean diameter of 193.2 nm, polydispersion index of 0.044, zeta potential of -23.3 mV and pH 6.32. The microdilution assay showed MIC of 15.5 mu g mL(-1) to GML Nanocapsules and 31.25 mu g mL(-1) to GML. The anti-biofilm assay showed the significantly reduction of biomass of C albicans biofilm treated with GML Nanocapsules while the GML does not exhibit effect. The kinetic assay demonstrated that at 48 h, the GML Nanocapsules reduce 94% of formed biofilm. The positive results suggest the promisor alternative for this public health problem that is biofilm infections. (C) 2016 Elsevier Ltd. All rights reserved.
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