Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 59, Pages 11783-11786Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04058b
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Funding
- NSERC Discovery Grant
- MSFHR Career Investigator Award
- NSERC Postgraduate Scholarship
- Hoffmann-La Roche PostDoc Fellowship (RPF)
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The late-stage fluorination of common synthetic building blocks and drug leads is an appealing reaction for medicinal chemistry. In particular, fluorination of benzylic C-H bonds provides a means to attenuate drug metabolism at this metabolically labile position. Here we report two complimentary strategies for the direct fluorination of benzylic C-H bonds using N-fluorobenzenesulfonimide and either a decatungstate photocatalyst or AIBN-initiation.
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