4.7 Article

A thiol-thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 80, Pages 14913-14916

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05390k

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Funding

  1. Lanzhou University [lzujbky-2014-56]
  2. Natural Science Foundation of Gansu Province [145RJZA225]

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The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response and quantitative reaction towards thiols. The structural novelty of BODIPY-TS would guide the development of novel thiol probes.

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