Journal
MICROBIAL DRUG RESISTANCE
Volume 22, Issue 5, Pages 379-386Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2015.0215
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Funding
- Queen Mary University London
- Pfizer/Wyeth
- Basilea
- Astellas
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Providencia stuartii has emerged as an important nosocomial pathogen. Wedescribe an outbreak due to a multidrug-resistant strain over a 4-month period in a critical care unit in Athens. Molecular typing revealed each of the isolates to be clonally related with coresistance to cephalosporins, carbapenems, aminoglycosides, and quinolones. Each isolate contained a 220-kbmulti-replicon (IncA/C and IncR) conjugative plasmid encoding TEM-1, SHV-5, VEB-1, and VIM-1 beta-lactamases and the 16S rDNA methylase RmtB. Antimicrobial therapy was unsuccessful in 3 of 6 cases, and resistance was readily transmissible to susceptible strains of Escherichia coli by transformation and conjugation. This highlights the clinical importance of P. stuartii and its ability to disseminate critical resistance determinants to other bacterial pathogens.
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