Journal
MICROBIAL CELL FACTORIES
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12934-016-0507-6
Keywords
Trichoderma reesei; Cellulase; Recombinant protein production; Biorefinery; Lignocellulose; Gene expression; Consolidated bioprocessing
Categories
Funding
- Austrian Science Fund [P24219-B21]
- Federal Ministry of Science, Research and Economy (BMWFW)
- Federal Ministry of Traffic, Innovation and Technology (bmvit)
- Styrian Business Promotion Agency SFG
- Standortagentur Tirol
- Government of Lower Austria
- Business Agency Vienna through the COMET-Funding Program
- TU Wien
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More than 70 years ago, the filamentous ascomycete Trichoderma reesei was isolated on the Solomon Islands due to its ability to degrade and thrive on cellulose containing fabrics. This trait that relies on its secreted cellulases is nowadays exploited by several industries. Most prominently in biorefineries which use T. reesei enzymes to saccharify lignocellulose from renewable plant biomass in order to produce biobased fuels and chemicals. In this review we summarize important milestones of the development of T. reesei as the leading production host for biorefinery enzymes, and discuss emerging trends in strain engineering. Trichoderma reesei has very recently also been proposed as a consolidated bioprocessing organism capable of direct conversion of biopolymeric substrates to desired products. We therefore cover this topic by reviewing novel approaches in metabolic engineering of T. reesei.
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