4.7 Review

Versatile biocatalysis of fungal cytochrome P450 monooxygenases

Journal

MICROBIAL CELL FACTORIES
Volume 15, Issue -, Pages -

Publisher

BIOMED CENTRAL LTD
DOI: 10.1186/s12934-016-0523-6

Keywords

Cytochrome P450; Cytochrome P450 reductase; Monooxygenase reaction; Biocatalysis; Fungi

Funding

  1. Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea, Korea [HN12C0055]
  2. Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology, Korea [NRF-2013R1A2A2A01068013]
  3. Korea Health Promotion Institute [HN12C0055020015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  4. National Research Foundation of Korea [2013R1A2A2A01068013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Cytochrome P450 (CYP) monooxygenases, the nature's most versatile biological catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a wide range of substrates under mild reaction conditions, thereby addressing a significant challenge in chemocatalysis. Though CYP enzymes are ubiquitous in all biological kingdoms, the divergence of CYPs in fungal kingdom is manifold. The CYP enzymes play pivotal roles in various fungal metabolisms starting from housekeeping biochemical reactions, detoxification of chemicals, and adaptation to hostile surroundings. Considering the versatile catalytic potentials, fungal CYPs has gained wide range of attraction among researchers and various remarkable strategies have been accomplished to enhance their biocatalytic properties. Numerous fungal CYPs with multispecialty features have been identified and the number of characterized fungal CYPs is constantly increasing. Literature reveals ample reviews on mammalian, plant and bacterial CYPs, however, modest reports on fungal CYPs urges a comprehensive review highlighting their novel catalytic potentials and functional significances. In this review, we focus on the diversification and functional diversity of fungal CYPs and recapitulate their unique and versatile biocatalytic properties. As such, this review emphasizes the crucial issues of fungal CYP systems, and the factors influencing efficient biocatalysis.

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