Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 85, Pages 15510-15513Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05798a
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Funding
- National Natural Science Foundation of China [21076035, 20972022]
- Program for New Century Excellent Talents in University [NCET-11-0053]
- Fundamental Research Funds of the Central Universities [DUT13ZD202]
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The catalytic asymmetric three-component 1,3-dipolar cycloaddition of 3-amino oxindoles with aldehydes and nitroolefins under the catalysis of a chiral phosphoric acid is reported. The reaction provides a facile approach to synthesize a diverse array of spiro[pyrrolidine-2,3'-oxindoles] in high yields with excellent diastereo-and enantioselectivities under mild conditions.
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