Journal
MICROBES AND INFECTION
Volume 18, Issue 10, Pages 649-655Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2016.05.007
Keywords
Diabetes; Klebsiella pneumoniae; Lung; Pneumonia
Categories
Funding
- National Institutes of Health grants [HL081149, AI057588]
- Research Council of Norway
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Diabetes is associated with increased susceptibility to Klebsiella pneumoniae and poor prognosis with infection. We demonstrate accelerated mortality in mice with streptozotocin-induced diabetes following tracheal instillation of K. pneumoniae. Diabetic mice recruited fewer granulocytes to the alveolar airspace and had reduced early production of CXCL1, CXCL2, IL-1 beta and TNF-alpha following tracheal instillation of K. pneumoniae-lipopolysaccharide. Additionally, TLR2 and TIRAP expression following K. pneumoniae-lipopolysaccharide exposure was decreased in hyperglycemic mice. These findings indicate that impaired innate sensing and failure to rapidly recruit granulocytes to the site of infection is a mechanism for diabetic susceptibility to respiratory K. pneumoniae infection. (C) 2016 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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