Optimization of Metal Oxide Nanosensors and Development of a Feature Extraction Algorithm to Analyze VOC Profiles in Exhaled Breath

Article Gastroenterology & Hepatology

Electronic nose versus quadrupole mass spectrometry for identifying viral hepatitis C patients

Ehab Mohamed et al.

Summary: The study utilized Electronic Nose and Mass Spectrometry technologies to analyze blood samples from hepatitis C patients and healthy controls, identifying specific volatile organic compounds for diagnosing hepatitis C.

JOURNAL OF VIRAL HEPATITIS (2022)

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Review Biochemical Research Methods

Review of the algorithms used in exhaled breath analysis for the detection of diabetes

Anna Paleczek et al.

Summary: Currently, intensive research is being conducted on the development of truly noninvasive medical diagnostic systems, including respiratory analysers based on the detection of biomarkers for various diseases like diabetes. Selective detection of diabetes biomarkers in exhaled breath is crucial, with algorithms trained to detect diabetes achieving over 90% accuracy in most cases.Various measurement systems, feature extraction methods, and algorithms such as support vector machines are being used to detect diabetes in patient samples and simulated artificial breath samples.

JOURNAL OF BREATH RESEARCH (2022)

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Article Automation & Control Systems

A Novel Multisensor Detection System Design for Low Concentrations of Volatile Organic Compounds

Junhui Qian et al.

Summary: In this article, a novel multisensor odor detection system for low-concentration VOCs is investigated. The designed conformal symmetric preconcentration unit structure and the developed application scheme demonstrate the effectiveness of the system and its potential for practical applications.

IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS (2022)

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Article Medicine, General & Internal

An Experimental Apparatus for E-Nose Breath Analysis in Respiratory Failure Patients

Carmen Bax et al.

Summary: A novel sampling system was developed for analyzing exhaled breath in respiratory failure patients, showing good tolerance and successful discrimination by support vector machine between respiratory failure patients and controls.

DIAGNOSTICS (2022)

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Proceedings Paper Materials Science, Multidisciplinary

Design and construction of a portable e-nose system for human exhaled breath VOC analysis

V. A. Binson et al.

Summary: This paper describes the design and fabrication of a system that can analyze the volatile organic compounds (VOCs) in human exhaled breath. The system, including an electronic nose with metal oxide semiconductor (MOS) gas sensors, control circuit, and processing circuit, has been tested and verified for detecting breath VOCs. A small pilot study involving lung cancer patients, chronic obstructive pulmonary disease patients, asthma patients, and healthy controls was conducted to check the clinical feasibility of the system. The results demonstrate that the developed e-nose system, using TGS gas sensors, is cost-effective and non-invasive, and it will be a diagnostic tool for detecting lung cancer, COPD, and other major respiratory diseases in the near future.

MATERIALS TODAY-PROCEEDINGS (2022)

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Article Biochemical Research Methods

Adsorption kinetics feature extraction from breathprint obtained by graphene based sensors for diabetes diagnosis

Ramji Kalidoss et al.

Summary: Multiple studies have shown the correlation between blood glucose and breath acetone, which has led to the development of an electronic nose for diabetes diagnosis. The research validated graphene based sensors for acetone concentration, demonstrating their potential in breath analysis for diabetes diagnosis. Features extraction and classification models were found to improve the accuracy of the sensors in-house fabricated graphene based sensors.

JOURNAL OF BREATH RESEARCH (2021)

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Review Chemistry, Analytical

An Outlook of Recent Advances in Chemiresistive Sensor-Based Electronic Nose Systems for Food Quality and Environmental Monitoring

Alishba T. John et al.

Summary: Electonic noses, relying on an array of chemical gas sensors, are used for identifying various compounds, particularly in the food industry and environmental monitoring. Advances in nanofabrication, sensor design, neural networks, and system integration have improved their efficacy. Commercial and custom Enoses face challenges in wider adoption and use across different applications.

SENSORS (2021)

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Review Chemistry, Analytical

Chemical Gas Sensors: Recent Developments, Challenges, and the Potential of Machine Learning-A Review

Usman Yaqoob et al.

Summary: There is a growing interest in smart gas sensors that are fast, accurate, and highly sensitive, driven by the demand for environmental safety and healthcare applications. Research has focused on developing sensors with novel materials for enhanced selectivity, although challenges remain in terms of selectivity. Machine learning techniques show promise in developing highly selective smart gas sensors.

SENSORS (2021)

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Article Chemistry, Analytical

Selective gas detection of H2 and CO by a single MOX-sensor

A. V. Shaposhnik et al.

Summary: This study explored the selective analysis of hydrogen, carbon monoxide, and their mixtures in air using a SnO2-based metal oxide sensor with the addition of PdOx. By employing a single MOX sensor, quantitative and qualitative analysis of gases were conducted with a focus on a small number of training sample concentrations. The effect of air humidity on the accuracy of gas concentration determination was also investigated, and PCA regression analysis algorithms were used to reduce multidimensional data. Temperature modulation of the SnO2 sensor with PdOx led to a significant increase in sensor responses for gas concentrations ranging from 10 to 100 ppm compared to the stationary temperature regime.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Nanoscience & Nanotechnology

Volatile Organic Compound Sensors Based on 2D Materials

Wee Chong Tan et al.

Summary: This article discusses the increasing interest in 2D inorganic materials (2DMs) and the advancements in sensors for measuring volatile organic compounds (VOCs) in ambient air. It explores commercially available sensors, such as amperometric and conductometric types, as well as the latest developments in VOC sensors using 2DMs and their nanocomposites. The performance and challenges of these VOC sensors are summarized in graphical form.

ADVANCED ELECTRONIC MATERIALS (2021)

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Review Chemistry, Analytical

Expanding Horizons of Metal Oxide-based Chemical and Electrochemical Sensors

K. S. Shalini Devi et al.

Summary: Metal-oxide sensors, with their quick response ability and high surface-to-volume ratio, are widely used in environmental monitoring and hazard surveillance, and can also be utilized for non-invasive health monitoring.

ELECTROANALYSIS (2021)

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Review Instruments & Instrumentation

Breath analysis for the screening and diagnosis of diseases

V. R. Nidheesh et al.

Summary: Exhaled breath contains a variety of VOCs that can provide valuable information about health status. Analysis and detection of these VOCs at low levels in breath can be correlated with certain diseases and serve as biomarkers for ailments, with potential applications in disease screening and early detection.

APPLIED SPECTROSCOPY REVIEWS (2021)

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Article Engineering, Environmental