Journal
METHODS
Volume 103, Issue -, Pages 86-98Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2016.04.004
Keywords
RNA secondary structure prediction; Structure probing
Funding
- Austrian Science Fund (FWF) [F43]
- Austrian Scinece Fund (FWF) [FWF-I-1804-N28]
- French Agence Nationale de la Recherche [ANR-14-CE34-0011]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE34-0011] Funding Source: Agence Nationale de la Recherche (ANR)
- Austrian Science Fund (FWF) [I1804] Funding Source: Austrian Science Fund (FWF)
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RNA secondary structures have proven essential for understanding the regulatory functions performed by RNA such as microRNAs, bacterial small RNAs, or riboswitches. This success is in part due to the availability of efficient computational methods for predicting RNA secondary structures. Recent advances focus on dealing with the inherent uncertainty of prediction by considering the ensemble of possible structures rather than the single most stable one. Moreover, the advent of high-throughput structural probing has spurred the development of computational methods that incorporate such experimental data as auxiliary information. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.
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