Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 20, Pages 4129-4143Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc10432c
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Funding
- 973 program of MOST of China [2014CB845605]
- Special Project of National Major Scientific Equipment Development of China [2012YQ120060]
- NSFC [11204302, 11304314, U1305244, U1405229, 21325104]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- CAS Cross-Disciplinary AMP
- Collaborative Research Team Program
- CAS Strategic Priority Research Program [XDA09030307]
- Fujian Provincial Natural Science Foundation [2013J05038]
- Science and Technology of Fujian Province [2013H0060]
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Time-resolved (TR) photoluminescence (PL) biosensing has been widely adopted in many research and medical institutions. However, commercial molecular TRPL bioprobes like lanthanide (Ln(3+))-chelates suffer from poor photochemical stability and long-term toxicity. Inorganic Ln(3+)-doped nanocrystals (NCs), owing to their superior physicochemical properties over Ln(3+)-chelates, are regarded as a new generation of luminescent nanoprobes for TRPL biosensing. The long-lived PL of Ln(3+)-doped NCs combined with the TRPL technique is able to completely suppress the interference of the short-lived background, resulting in a background-free signal and therefore a remarkable sensitivity for biosensing. In this feature article, we summarize the latest advancements in inorganic Ln(3+)-doped NCs as TRPL nano-bioprobes from their fundamental optical properties to their potential applications for ultrasensitive biodetection and high-resolution bioimaging. Future efforts towards the commercialization of these nanoprobes are also proposed.
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