Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 32, Pages 6936-6939Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00501a
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Funding
- National Natural Science Foundation of China [51125014, 21204068, 51233003]
- Ministry of Science and Technology of China [2011CB606202]
- Natural Science Foundation of Hubei Province of China [2013CFA003]
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We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor cells and show more than 2-fold higher cytotoxicity (IC50 = 0.38 mg L-1) than that towards normal cells (IC50 = 0.89 mg L-1).
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