Key metabolomic alterations are associated with ulcerative colitis disease state and activity: a validation analysis

Article Gastroenterology & Hepatology

Microbial determinants of effective donors in faecal microbiota transplantation for UC

Craig Haifer et al.

Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.

GUT (2023)

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Article Gastroenterology & Hepatology

Faecal metabolome and its determinants in inflammatory bowel disease

Arnau Vich Vila et al.

Summary: By analyzing the metabolites in fecal samples of patients with inflammatory bowel disease (IBD) and non-IBD controls, along with fecal metagenomics, host genetics, and clinical characteristics, we aimed to reveal metabolic alterations in IBD. The study identified over 300 molecules that were differentially abundant in the feces of patients with IBD, and a specific ratio between a sphingolipid and L-urobilin could distinguish between IBD and non-IBD samples. Additionally, strong associations were found between gut microbiota and fecal metabolome, paving the way for future interventions targeting intestinal inflammation.

GUT (2023)

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Article Multidisciplinary Sciences