Journal
GROWTH FACTORS
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08977194.2023.2239356
Keywords
Transforming growth factor-beta; airway remodelling; bronchiolitis obliterans; extracellular matrix; epithelial-mesenchymal transition
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This review examines the role of transforming growth factor-beta (TGF-beta) in airway remodelling in bronchiolitis obliterans (BO) and its potential as a therapeutic target. It highlights the mechanisms of TGF-beta activation and signalling, cellular targets of TGF-beta actions, and research progress in TGF-beta signalling and TGF-beta-mediated processes.
Airway remodelling is the main pathological mechanism of bronchiolitis obliterans (BO). Several studies have found that transforming growth factor-beta (TGF-beta) expression is increased in BO during airway remodelling, where it plays an important role in various biological processes by binding to its receptor complex to activate multiple signalling proteins and pathways. This review examines the role of TGF-beta in airway remodelling in BO and its potential as a therapeutic target, highlighting the mechanisms of TGF-beta activation and signalling, cellular targets of TGF-beta actions, and research progress in TGF-beta signalling and TGF-beta-mediated processes.
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